One-Step Cartilage Repair with Bone Marrow Aspirate Concentrated Cells and Collagen Matrix in Full-Thickness Knee Cartilage Lesions

Gobbi, Alberto; Karnatzikos, Georgios; Scotti, Celeste; Mahajan, Vivek; Mazzucco, Laura; Grigolo, Brunella

doi:10.1177/1947603510392023

Cited by 219 publications

(189 citation statements)

References 49 publications

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“…Sto sun ko wo nie daw no roz po czę to sto so wa nie jed no eta po wych pro ce dur ope ra cyj nych, gdzie ho dowa ne chon dro cy ty za stą pio no me zen chy mal ny mi ko mór ka mi ma cie rzy sty mi po zy ski wa ny mi naj czę -ściej z krwi, szpi ku lub tkan ki tłusz czo wej [7,8,9,10,11,12].…”

Section: Wstępunclassified

“…Po po bra niu chon dro cy tów ist nie je ko niecz ność ich na mno że nia w la bo ra to rium i na stęp nie ich wszcze pie nia. Z uwa gi na ho dow lę w wa run kach la bo ra toryj nych, jak i 2 se an se ope ra cyj ne, pro ce du ra ta jest wy so ce kosz tow na i bar dziej kło po tli wa dla pa cjen ta.Sto sun ko wo nie daw no roz po czę to sto so wa nie jed no eta po wych pro ce dur ope ra cyj nych, gdzie ho dowa ne chon dro cy ty za stą pio no me zen chy mal ny mi ko mór ka mi ma cie rzy sty mi po zy ski wa ny mi naj czę -ściej z krwi, szpi ku lub tkan ki tłusz czo wej [7,8,9,10,11,12].W na szym ośrod ku do re kon struk cji głę bo kich ubyt ków chrzęst no -kost nych sto so wa no kon cen trat ko mó rek szpi ku kost ne go oraz me zen chy mal ne komór ki ma cie rzy ste po zy ska ne z krwi ob wo do wej.Wstęp ne wy ni ki le cze nia cho rych by ły sa tys fakcjo nu ją ce w oce nie ope ra to rów i in spi ro wa ły do dalszych ob ser wa cji, Ce lem pra cy by ła oce na od le głych wy ni ków kli nicz nych po re kon struk cji roz le głych ubyt ków chrzęst no -kost nych w dwóch gru pach cho rych za opatrzo nych z uży ciem me zen chy mal nych ko mó rek macie rzy stych z krwi lub kon cen tra tu ko mó rek szpi ku. …”

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“…One-stage surgical procedures have recently been introduced with chondrocyte multiplication replaced with mesenchymal stem cells most commonly obtained from blood, bone marrow or adipose tissue [7,8,9,10,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Osteochondral lesions of the knee reconstructed with mesenchymal stem cells – results.

Skowroński¹,

Rutka²

2013

Ortop Traumatol Rehabil

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mó rek szpi ku. Material i metody. Ma te riał kli nicz ny sta no wi ło 46 pa cjen tów z ubyt ka mi chrzęst no -kost ny mi o ró żnej etiolo gii, po twier dzo ny mi w MRI, w dwóch gru pach: 21 cho rych za opa trzo nych z uży ciem kon cen tra tu ko mó rek szpiku i 25 cho rych le czo nych za po mo cą ko mó rek me zen chy mal nych uzy ska nych z krwi ob wo do wej. Oce nę przepro wa dzo no po 6 mie sią cach, 1 ro ku i 5 lat po re kon struk cji ubyt ku na pod sta wie skal: KO OS, Ly shol ma i VAS.Wy ni ki. Au to rzy uzy ska li istot ną po pra wę we wszyst kich ska lach ocen u 40 ope ro wa nych pa cjen tów (86%). U 6 cho rych od no to wa no wy nik zły. Wy ka za no istot ną sta ty stycz nie ró żni cę w gru pach po rów ny wanych na ko rzyść cho rych le czo nych ko mór ka mi ma cie rzy sty mi po zy ska ny mi z krwi. Oce na ob ra zów MRI, u cho rych z wy ni ka mi do bry mi i bar dzo do bry mi, wy ka za ła za do wa la ją cą od bu do wę po wierzch ni chrzęst nej oraz do brą in te gra cję re ge ne ra tu. Po 5-ciu la tach od no to wa no nie wiel ki spa dek śred niej ocen kli nicz nych w obu gru pach cho rych.Wnio ski. 1. Re kon struk cja z uży ciem zmo dy fi ko wa nej tech ni ki ka nap ko wej jest sku tecz ną me to dą le czenia głę bo kich ubyt ków chrzęst no -kost nych sta wu ko la no we go. 2. Nie co gor sze wy ni ki w gru pie le czo nej koncen tra tem ko mó rek szpi ku mo że mieć swą przy czy nę w licz bie po da nych ko mó rek ma cie rzy stych.Sło wa klu czo we: cho ro by chrząst ki, mar twi ca chrzęst no -kost na, ko mór ki ma cie rzy ste, chi rur gia re kon struk cyj na SUM MA RY Background. We pre sent the re sults of the tre at ment of oste ochon dral le sions with the mo di fied san dwich tech ni que with a col la gen mem bra ne. The aim of the stu dy was to as sess and com pa re cli ni cal out co mes fol lowing the re con struc tion of oste ochon dral le sions in two gro ups of pa tients tre ated with stem cells ob ta ined from blo od and with bo ne mar row con cen tra te.Material and methods. The stu dy gro up com pri sed 46 pa tients with MRI -con fir med oste ochon dral le sions of va rio us aetio lo gy. A gro up of 21 pa tients was tre ated with bo ne mar row con cen tra te and 25 pa tients we re treated with me sen chy mal cells ob ta ined from pe ri phe ral blo od. Pa tients we re as ses sed with the use of KO OS, Lysholm and VAS sca les at 6 mon ths, and at 1 and 5 years fol lo wing the re con struc tion.Re sults. We no ted a si gni fi cant im pro ve ment across all sca les in 40 pa tients (86%). A po or out co me was no ted in 6 pa tients. The re was a sta ti sti cal ly si gni fi cant su pe rio ri ty of the gro up tre ated with stem cells ob ta ined from blo od. The ana ly sis of MRI evi den ce in pa tients with go od and excel lent re sults sho wed sa tis fac to ry recon struc tion of the car ti la gi no us sur fa ce and go od re ge ne ra te in te gra tion. At 5 years, a sli ght de cre ase in me an cli ni cal as ses sment sco res was se en in both gro ups of pa tients.Conc lu sions. 1. The mo di fied san dwich...

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Section: Wstępunclassified

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Osteochondral lesions of the knee reconstructed with mesenchymal stem cells – results.

Skowroński¹,

Rutka²

2013

Ortop Traumatol Rehabil

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“…Along these lines, Gobbi et al (56) published the first case of stem cell transplantation using the onestep procedure to operate on a knee, with two years of follow-up. The procedure consisted of using bone marrow cells together with scaffolds of types I and III collagen.…”

Section: One-step Stem Cell Transplantationmentioning

confidence: 99%

Atualização no diagnóstico e tratamento das lesões condrais do joelho

Filho¹,

Doca²,

Cohen³

et al. 2012

Rev. bras. ortop.

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“…[86][87][88] Several studies have reported BMC to be effective in treatment of early knee OA and moderate focal chondral defects.…”

mentioning

confidence: 99%

Emerging Potential of Cell Based Therapies for Articular Cartilage Repair and Regeneration

Venkatesh¹

2017

ATROA

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Abbreviations: ACI, autologous chondrocyte implantation;MSCs, mesenchymal stem cells; PRP, platelet-rich plasma; BMC, autologous bone marrow concentrate; TKR, total knee replacement IntroductionOsteoarthritis is a form of arthritis described as a degenerative joint disease that results from the breakdown of articular cartilage and underlying subchondral bone.1,2 Cartilage is firm, rubbery, protein substance that serves as a "cushion" between the bones, providing a smooth, gliding surface for joint motion. As the cartilage breaks down, it causes pain, swelling, stiffness and problems moving the joint.3 Therefore, Osteoarthritis is a chronic disease and a major cause of disability, characterized by irreversible cartilage degeneration, bony changes of the joints, deterioration of tendons and ligaments, and inflammation of the synoviumas shown in Figure 1. 4 An initial degeneration, known as the 'pre-OA' state may be reversible spontaneously or through preventive measures, however, if not stopped, the disease progresses to later stages which results in loss of articular cartilage surface integrity, break down of bone and osteophyte formation.3,5 OA can affect any joint, but it most often occurs in the knee, hip, lower back and neck, small joints in the finger and base of the big toe ( Figure 2). 6,7Osteoarthritis of the knee is the most common chronic condition affecting all races, gender and ages, but known to be the most common in elderly and obese people. 8,9 The knee acts as a conduit for transferring body weight essential for normal human mobility and the menisci is known to maintain the normal function of the knee, distribute load, lubricate the joint and provide joint stability. Injury to the meniscus from ageing cartilage, repetitive activity or trauma results in pain, limits movement and can accelerate the occurrence and development of OA. In general, partial or complete meniscectomy causes OA of the knee. 8,10,11 While the prevalence of OA increases with age and causes significant decline in the quality of life of individuals above the age of 65, there is increasing evidence of OA in younger population as a result of prior injuries such as anterior cruciate ligament tear or meniscal tears. 8,12,13 Figure 1 Comparison schematic between healthy knee and arthritic knee.Osteoarthritis affects about 237 million of the population, of which an estimated 9 million people alone in United States suffer from symptomatic knee osteoarthritis and it is predicted that an additional 19 million people will be affected by arthritis by 2020. 14-17The incidence of chondral defects is frequent with sporting injuries, and in elderly patients specifically 10% of population over the age of 55 years have troublesome knee pain, and of those, 25% are severely disabled.18 Depending on disease severity, management ranges from conservative treatment to surgical intervention, including total knee replacement. 14,19 In recent years the number and cost of TKR has increased dramatically between 2001 and 2012 from 305,000 to 610,000 procedu...

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One-Step Cartilage Repair with Bone Marrow Aspirate Concentrated Cells and Collagen Matrix in Full-Thickness Knee Cartilage Lesions

Cited by 219 publications

References 49 publications

Osteochondral lesions of the knee reconstructed with mesenchymal stem cells – results.

Osteochondral lesions of the knee reconstructed with mesenchymal stem cells – results.

Atualização no diagnóstico e tratamento das lesões condrais do joelho

Emerging Potential of Cell Based Therapies for Articular Cartilage Repair and Regeneration

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