One-step biological synthesis of cauliflower-like Ag/MgO nanocomposite with antibacterial, anticancer, and catalytic activity towards anthropogenic pollutants

Jayapriya, M.; Premkumar, Kumpati; Senthilkumar, N.; Karthikeyan, K.

doi:10.1007/s11164-019-04062-1

Cited by 35 publications

(8 citation statements)

References 52 publications

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“…The antibacterial activity of the MgO-NPs against E . coli was also considered comparable with the silver/ MgO nanocomposites produced by using Musa paradisiaca extract [ 84 ]. The lipid peroxidation and reactive oxidative species production processes in the container have been responsible for the antibacterial ability of MgO-NPs [ 85 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported the efficacy of MgO-NPs and other metallic nanoparticles on antibacterial behavior on the occurrence of oxygen vacancies on the surface of the nanoparticles, which contributed to lipid peroxidation and production of reactive oxygen species [72,73]. The antibacterial activity of the MgO-NPs against E. coli was also considered comparable with the silver/ MgO nanocomposites produced by using Musa paradisiaca extract [84]. The lipid peroxidation and reactive oxidative species production processes in the container have been responsible for the antibacterial ability of MgO-NPs [85].…”

Section: Minimum Inhibitory Concentrationmentioning

confidence: 94%

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Phytoassisted synthesis of magnesium oxide nanoparticles from Pterocarpus marsupium rox.b heartwood extract and its biomedical applications

Manne

Viswanath

Giduturi

et al. 2021

Journal of Genetic Engineering and Biotechnology

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Background Unlike chemical techniques, the combination of metal oxide nanoparticles utilizing plant concentrate is a promising choice. The purpose of this work was to synthesize magnesium oxide nanoparticles (MgO-NPs) utilizing heartwood aqueous extract of Pterocarpus marsupium. The heartwood extract of Pterocarpus marsupium is rich in polyphenolic compounds and flavonoids that can be used as a green source for large-scale, simple, and eco-friendly production of MgO-NPs. The phytoassisted synthesis of MgO is characterized by UV-Visible spectroscopy, X-ray diffraction (XRD), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) with EDS (energy dispersive X-ray spectroscopy), and transmission electron microscopy (TEM). Results The formation of MgO-NPs is confirmed by a visual color change from colorless to dark brown and they displayed a wavelength of 310 nm in UV-Spectrophotometry analysis. The crystalline nature of the obtained biosynthesized nanoparticles are revealed by X-ray diffraction analysis. SEM results revealed the synthesized magnesium oxide nanoparticles formed by this cost-effective method are spherically shaped with an average size of < 20 nm. The presence of magnesium and oxygen were confirmed by the EDS data. TEM analysis proved the spherical shape of the nanoparticles with average particle size of 13.28 nm and SAED analysis confirms the crystalline nature of MgO-NPs. FT-IR investigation confirms the existence of the active compounds required to stabilize the magnesium oxide nanoparticles with hydroxyl and carboxyl and phenolic groups that act as reducing, stabilizing, and capping agent. All the nanoparticles vary in particle sizes between 15 and 25 nm and obtained a polydispersity index value of 0.248. The zeta-potential was measured and found to be − 2.9 mV. Further, MgO-NPs were tested for antibacterial action against Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria) by minimum inhibitory concentration technique were found to be potent against both the bacteria. The blended nanoparticles showed good antioxidant activity examined by the DPPH radical scavenging method, showed good anti-diabetic activity determined by alpha-amylase inhibitory activity, and displayed strong anti-inflammatory activity evaluated by the albumin denaturation method. Conclusions The investigation reports the eco-friendly, cost-effective method for synthesizing magnesium oxide nanoparticles from Pterocarpus marsupium Rox.b heartwood extract with biomedical applications. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Section: Minimum Inhibitory Concentrationmentioning

confidence: 94%

Phytoassisted synthesis of magnesium oxide nanoparticles from Pterocarpus marsupium rox.b heartwood extract and its biomedical applications

Manne

Viswanath

Giduturi

et al. 2021

Journal of Genetic Engineering and Biotechnology

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“…Considering all the facts, the catalytic reduction of aromatic nitro-derivative compound in the presence of nanoparticles is the most suitable method among the conventional methods for disposal of hazardous waste. In addition, the catalytic reduction process is green and economically facile [9][10][11]. The main advantage of catalytic reduction process is that the reduced products of aromatic nitro compounds can be reused for the synthesis of dyes and drugs [12,13].…”

Section: Introductionmentioning

confidence: 99%

Mussel-inspired Ag/poly(norepinephrine)/MnO2 heterogeneous nanocatalyst for efficient reduction of 4-nitrophenol and 4-nitroaniline: an alternative approach

et al. 2020

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Noble metal-based surface chemistry is a well-practiced domain on interest in catalysis. A newborn in mussel-inspired coating based on catecholic chemistry, poly(norepinephrine) (PNE), has been synthesized via cyclization polymerization technique over MnO 2 nanosheets. The physisorped PNE macromolecular chains over MnO 2 nanosheets act as green reducing agent for silver ions resulting in arresting the quasi-spherical silver nanoparticles distributed over the MnO 2-PNE assembly. The catalytic activity was performed against nitroaryl molecules which evidenced fast reduction with pseudo-first-order kinetics. The superiority which lies in this work is their facile preparation, high surface area due to sheet-like morphology, and fast catalytic reduction. These practical observations spread its window as nanocatalyst toward environmental remediation of hazardous nitroaryl compounds.

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“…The results illustrated the polymeric bionanocomposite induced more cell death than AgNPs due to the presence of magnesium oxide ions which are reported as a cytotoxic agent towards many cancer cell lines including MCF-7, HT 29, Hep2 cells ( Amina et al, 2020 , Saravanakumar and Wang, 2019 ). Furthermore, many studies have shown that the silver-doped nanoparticles can easily penetrate the cell membrane and induce the free radicals, production of ROS and trigger the damage of the nucleus ( Jayapriya et al, 2020 ). The morphological changes in the cell and membrane damage were observed under phase contrast microscopic analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The fabrication of these nanostructures involves various physiochemical procedures that have been generated hazardous byproducts, rigorous energy and harsh environmental conditions. Consequently, there is an increase demand for the development of a lucrative, environmentally friendly approach that gives a superior platform to synthesize the Ag/MgO bionanocomposite with a well-defined morphology that can serve as a potential candidate to resolve varied problems with multifunctional properties ( Jayapriya et al, 2020 , Ayinde et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Prospective of biosynthesized L.satiVum oil/PEG/Ag-MgO bionanocomposite film for its antibacterial and anticancer potential

Amina

Musayeib

Al-Hamoud

et al. 2021

Saudi Journal of Biological Sciences

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A substantial interest has been manifested in utilizing oil/metal oxide hybrid bionanocomposite, especially organic/ inorganic to design different biomedical applications. The present study reports the synthesis, characterization, antibacterial and anticancer properties of biogenic silver nanoparticles (AgNPs) and L.satiVum oil/PEG/Ag-MgO bionanocomposite. The fabricated AgNPs and L.sativum oil/PEG/Ag-MgO bionanocomposite were characterized by employing different spectroscopic (UV, FTIR, XRD) and microscopic (TEM, SEM) techniques. The particle size analysis showed that the mean size of 16.32 nm for AgNPS and 13.45 nm L.satiVum oil/PEG/Ag-MgO, indicating the excellent dispersion of Ag-MgO nanoparticles in the PEG– L.satiVum oil matrix. The antimicrobial activity of AgNPs and polymeric bionanocomposite was investigated against two pathogenic bacteria. The highest antibacterial effect was observed for bionanocomposite towards Gram-positive Staphylococcus aureus (27 mm) and Gram-negative Escherichia coli (25 mm) at 40 µg/well. The bionanocomposite completely vanished the bacterial growth (100%) at 80 µgmL −1 concentrations. Moreover, the AgNPs and polymeric bionanocomposite was evaluated for anticancer activity against human cervical cancer cells (HeLa cells) at different doses (50, 250, 500, and 1000 µgmL −1 ). The results showed polymeric bionanocomposite was stronger in inducing the HeLa cancer cell death than AgNPs. Overall, the fabricated L.satiVum oil/PEG/Ag-MgO bionanocomposite serve as a potential antimicrobial and anticancer agent and could be used in the development of novel drugs and health care products in near future.

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One-step biological synthesis of cauliflower-like Ag/MgO nanocomposite with antibacterial, anticancer, and catalytic activity towards anthropogenic pollutants

Cited by 35 publications

References 52 publications

Phytoassisted synthesis of magnesium oxide nanoparticles from Pterocarpus marsupium rox.b heartwood extract and its biomedical applications

Phytoassisted synthesis of magnesium oxide nanoparticles from Pterocarpus marsupium rox.b heartwood extract and its biomedical applications

Mussel-inspired Ag/poly(norepinephrine)/MnO2 heterogeneous nanocatalyst for efficient reduction of 4-nitrophenol and 4-nitroaniline: an alternative approach

Prospective of biosynthesized L.satiVum oil/PEG/Ag-MgO bionanocomposite film for its antibacterial and anticancer potential

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