Public research and development labs in Mexico are few and they have been created only in the last four decades. Little experience is available regarding successful organizational models, as well as best structure and processes in their design. Currently, the need for a research center on Genomics and Biodiversity has become increasingly important, and its design and creation is in process.The design of this center, however, is built on an analysis of similar research institutions abroad, as well as on the basis of what the specialized literature regards as best practices on several scores. For example, its structure and workflows, as well as its knowledge management practices and infrastructure will have to be carefully considered. Its impending creation will be of the utmost importance for the country, but it will also become a strategic competitor for international business in the field. This paper discusses the key issues in the design and creation of this organization, and in the development of its research capabilities.