One signal activated TIL enables potent anti-tumor activity across solid tumor types
Yongqiang Wu,
Xueshuai Ye,
Yufeng Zhu
et al.
Abstract:Adoptive T cell therapy (ACT) with autologous tumor-infiltrating lymphocytes (TIL) has shown compelling anti-tumor activity across various solid tumors. The function and status of TIL significantly influence its anti-tumor potential. In this study, we present the development of One-Signal-Activated TIL (OSAT), highlighting its robust anti-tumor activity in various syngeneic tumor models. We designed 10 unique signals by integrating CD3Z with a secondary signaling molecule. From these, we identified a specific … Show more
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