One‐Shot Immunomodulatory Nanodiamond Agents for Cancer Immunotherapy

Zhang, Yu; Cui, Zhifen; Kong, Huating; Xia, Kai; Pan, Liang; Li, Jiang; Sun, Yanhong; Shi, Jiye; Wang, Lihua; Zhu, Ying; Fan, Chunhai

doi:10.1002/adma.201506232

Cited by 109 publications

(82 citation statements)

References 53 publications

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“…Among a wide variety of nanomaterials-based vehicles, nanodiamonds (NDs) have shown outstanding delivery ability and excellent biocompatibility (Zhang et al, 2016). Zhao et al have demonstrated that detonation nanodiamond with hyperbranched polyglycerol coating (dND-PG) loaded with anticancer drug and led by efficient targeting moiety can realize highly preferential toxicity to the intended tumor cells through specific uptake mechanisms, while with minimum uptake and toxicity in macrophages (Zhao et al, 2014).…”

Section: Nanodiamondmentioning

confidence: 99%

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

et al. 2017

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Cancer stem cells (CSCs) have been identified in almost all cancers and give rise to metastases and can also act as a reservoir of cancer cells that may cause a relapse after surgery, radiation, or chemotherapy. Thus they are obvious targets in therapeutic approaches and also a great challenge in cancer treatment. The threat presented by CSCs lies in their unlimited proliferative ability and multidrug resistance. These findings have necessitated an effective novel strategy to target CSCs for cancer treatment. Nanomaterials are on the route to providing novel methods in cancer therapies. Although, there have been a large number of excellent work in the field of targeted cancer therapy, it remains an open question how nanomaterials can meet future demands for targeting and eradicating of CSCs. In this review, we summarized recent and highlighted future prospects for targeting CSCs for cancer therapies by using a variety of nanomaterials.

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Section: Nanodiamondmentioning

confidence: 99%

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

et al. 2017

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“…The CpG ODNs, generally present in bacterial and viral DNA, can be recognized by mammalian immune system through Toll‐like receptor 9 (TLR9) and promote the secretion of a series of proinflammatory cytokines . Although the use of CpG ODNs has been proved an enhancement of immunity and various nanomaterials have been studied for delivering CpG ODNs into target cells, yet the costly materials, the lengthy fabrication processes, and the inability to deliver the CpG ODNs together with antigens into the same cells by using these delivery vehicles hamper their further application. The OVA@ZIF‐8‐CpG nanoparticles could be synthesized easily and economicly.…”

Section: Introductionmentioning

confidence: 99%

Metal‐Organic‐Framework‐Based Vaccine Platforms for Enhanced Systemic Immune and Memory Response

Zhang

Wang

et al. 2016

Adv Funct Materials

228

199

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Nanoparticulate delivery platforms have shown promising advantages for vaccines in many aspects. However, their application was limited so far by lengthy synthetic protocols, the requirement of specific modification of antigen, and by the low efficiency in inducing antigen‐specific cytotoxic T‐lymphocyte responses. This study demonstrates for the first time the construction of metal‐organic‐framework (MOF) based vaccines by encapsulating ovalbumin (OVA) and attaching the cytosine‐phosphate‐guanine oligodeoxynucleotides (CpG ODNs) in/on zeolitic imidazolate framework‐8 (ZIF‐8) nanoparticles. The pH responsive decomposition feature enables the system to release the protein antigens and CpG ODNs in the same antigen presenting cells more efficiently. More importantly, in addition to the induction of a potent immune memory response, both in vitro and in vivo experiments show that the vaccines can induce strong humoral and cellular immunity. These findings suggest that the MOF‐based vaccine platforms can be used to produce effective vaccines against a range of ailments, which will facilitate the application of MOFs in biomedical areas.

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“…Nanomaterials are defined as materials with sizes ranging from 1 to 1000 nm in at least 1D. Due to the unique physicochemical properties such as higher surface area‐to‐volume ratio and enhanced permeability and retention (EPR) effect, they have presented promising application potential in diagnosis and therapy for various kinds of diseases . On the other hand, these properties possessed by nanomaterials are not always helpful, accumulating evidences indicate that the nanosized crystals could induce much greater toxicity than similar bulk materials and even affect the cell death mode .…”

Section: Introductionmentioning

confidence: 99%

Harnessing Calcium‐Oxalate‐ (CaOx‐) Nanocrystal‐Induced Prodeath Autophagy for Attenuating Human Renal Proximal Tubular Epithelial Cell Injury

Chen

Wei

Meng

et al. 2019

Part & Part Syst Charact

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Calcium oxalate (CaOx) stone is the most common type of kidney stone, with a formation process comprising supersaturation, nucleation, growth, aggregation to crystals, and adhesion on renal tubular epithelial cells. CaOx stones generally lead to renal injury; however, the underlying mechanism remains poorly understood. Accumulating evidence suggests that nanosized materials could induce much greater toxicity than bulk materials with the same components. As aggregation to nanocrystals is necessary to form CaOx stones and nanocrystals have been widely reported to elicit either prodeath or prosurvival autophagy, the aim is to address the precise role of autophagy in CaOx‐ nanocrystal‐induced cytotoxicity. Clinical CaOx stones from patients are collected followed by ball milling. As a result, CaOx nanocrystals significantly reduce renal cell viability in a dose‐ and time‐dependent manner. Further study shows that CaOx nanocrystals possess an autophagy‐inducing capacity and autophagic flux is complete. Autophagy abrogation by specific chemical inhibitor wortmannin or chloroquine obviously attenuates cytotoxicity, strongly suggesting that prodeath autophagy contributes to CaOx nanocrystals‐elicited cytotoxicity. Finally, it is revealed that autophagy is an essential signaling pathway participating in apoptosis regulation. Collectively, the findings demonstrate the role of autophagy in CaOx‐nanocrystal‐elicited cytotoxicity, and harnessing autophagy can be helpful to design promising strategies for attenuating kidney injury in nephrolithiasis.

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One‐Shot Immunomodulatory Nanodiamond Agents for Cancer Immunotherapy

Cited by 109 publications

References 53 publications

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

Metal‐Organic‐Framework‐Based Vaccine Platforms for Enhanced Systemic Immune and Memory Response

Harnessing Calcium‐Oxalate‐ (CaOx‐) Nanocrystal‐Induced Prodeath Autophagy for Attenuating Human Renal Proximal Tubular Epithelial Cell Injury

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