One Shoot, Two Birds: Alleviating Inflammation Caused by Ischemia/Reperfusion Injury to Reduce the Recurrence of Hepatocellular Carcinoma

Chen, Hao; Lu, Di; Yang, Xinyu; Hu, Zhihang; He, Chiyu; Li, Huigang; Lin, Zuyuan; Yang, Modan; Xu, Xiao Chun

doi:10.3389/fimmu.2022.879552

Cited by 16 publications

(11 citation statements)

References 106 publications

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“…176 In addition to direct anti-inflammation therapeutics, targeting ischemia injury could also effectively alleviate postoperative inflammation. 177 Hypothermic oxygenated perfusion, which is an emerging organ preservation strategy, could significantly improve oxidative stress and inflammation and thus decrease HCC recurrence risks after liver transplantation. 178…”

Section: Anti-inflammationmentioning

confidence: 99%

The tumor microenvironment in the postsurgical liver: Mechanisms and potential targets of postoperative recurrence in human hepatocellular carcinoma

Wang

et al. 2023

Medicinal Research Reviews

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Surgery remains to be the mainstay of treatment for hepatocellular carcinoma (HCC). Nonetheless, its therapeutic efficacy is significantly impaired by postoperative recurrence, which occurs in more than half of cases as a result of intrahepatic metastasis or de novo tumorigenesis. For decades, most therapeutic strategies on inhibiting postoperative HCC recurrence have been focused on the residual tumor cells but satisfying therapeutic outcomes are barely observed in the clinic. In recent years, a better understanding of tumor biology allows us to shift our focus from tumor cells toward the postoperative tumor microenvironment (TME), which is gradually identified to play a pivotal role in tumor recurrence. In this review, we describe various surgical stress and surgical perturbation on postoperative TME. Besides, we discuss how such alternations in TME give rise to postoperative recurrence of HCC. Based on its clinical significance, we additionally highlight the potential of the postoperative TME as a target for postoperative adjuvant therapeutics.

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Section: Anti-inflammationmentioning

confidence: 99%

The tumor microenvironment in the postsurgical liver: Mechanisms and potential targets of postoperative recurrence in human hepatocellular carcinoma

Wang

et al. 2023

Medicinal Research Reviews

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“…This translated into a higher 5-year tumor-free survival for recipients of HMP-treated livers. It is theorized that the HMP-associated reduction in IRI affects the inflammatory milieu of the liver, thereby decreasing tumor re-seeding and recurrence [22]. Second, Bruggenwirth et al analyzed outcomes of donor livers undergoing prolonged HMP treatment (>4 h) [23].…”

Section: New Opportunities and Expanded Applicationsmentioning

confidence: 99%

Using organ perfusion to optimize donor livers

Lee‐Riddle

Panayotova

Guarrera

2023

Current Opinion in Organ Transplantation

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Purpose of reviewThe shortage of donor organs has led to the use of marginal extended criteria donor (ECD) livers to increase access to liver transplant. Ex-vivo machine perfusion allows for treatment and assessment of organs during preservation, potentially facilitating safe use of ECD livers at risk for worse clinical outcomes. This article reviews the latest published literature on the application of ex-vivo machine perfusion technologies in liver transplantation. Recent findingsMultiple randomized controlled trials on the use of hypothermic machine perfusion (HMP) and normothermic machine perfusion (NMP) have been published in the past 5 years demonstrating improved graft function and decreased biliary complications after machine perfusion. Novel applications of machine perfusion include pretransplant organ viability testing, expansion to pediatric transplant, and prolonged preservation. SummaryThere is now a body of evidence that HMP and NMP treatment improves clinical outcomes in ECD livers. There is a wide horizon for future applications of these preservation techniques to further optimize donor livers and to facilitate more liver transplants for those on the waitlist.

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“…Changes in iatrogenically induced ischemia during hepatic resection have also been explored in order to reduce intraoperative bleeding such as selective portal clamping, maintaining arterial flow, and remote ischemic preconditioning. These strategies appear to reduce ischemia/reperfusion damage resulting in a positive effect in terms of the risk of HCC recurrence [38].…”

Section: Ischemia/reperfusion Injury Gut-liver Axis and Angiogenesismentioning

confidence: 99%

Hepatic Progression of Hepatocellular Carcinoma

Rossetto¹,

Rosignoli²,

Tatani³

et al. 2023

Liver Cancer - Genesis, Progression and Metastasis

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Hepatocellular carcinoma constitutes an ongoing challenge due to its incidence and the high mortality related to it. Metastases and relapses even after treatment with curative intent are frequent. The liver is a common site for metastasis because of anatomical and physiological reasons; its position, the particular cytoarchitecture and cell populations, and its peculiar immunologic properties make it a favorable and tolerogenic environment; the inflammatory state with the alteration of the cytoarchitecture and of the microcirculation associated, and gut permeability and metabolic diseases cause the development of a liable site to progression of hepatocellular carcinoma. The difficulty of always having an early diagnosis and the lack of therapeutic flow charts including the biological behavior of the disease have always posed great difficulties in dealing with it. In the last few years, mechanisms involved in the onset and in the progression of hepatocellular carcinoma are a source of great interest; the discovery of pro-neoplastic and pro-metastatic conditions, of the cross talk between organs and cells, of progression pathways, of mediators contributing to proliferation and metastasis and of modular check points, of miRNAs, all potential therapeutic targets, appear promising for transforming the approach to hepatocarcinoma, offering the possibility of earlier diagnosis, customizable treatments, and better outcome.

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One Shoot, Two Birds: Alleviating Inflammation Caused by Ischemia/Reperfusion Injury to Reduce the Recurrence of Hepatocellular Carcinoma

Cited by 16 publications

References 106 publications

The tumor microenvironment in the postsurgical liver: Mechanisms and potential targets of postoperative recurrence in human hepatocellular carcinoma

The tumor microenvironment in the postsurgical liver: Mechanisms and potential targets of postoperative recurrence in human hepatocellular carcinoma

Using organ perfusion to optimize donor livers

Hepatic Progression of Hepatocellular Carcinoma

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