One‐pot Two‐Step Cycloaddition Reaction for Convenient Synthesis of Polycyclic Spirooxindole‐fused [1,3]Oxazines

Abstract

The novel spirooxindoline fused [1,3]oxazines were efficiently synthesized from Diels-Alder reaction of, which were generated in situ from three-component reactions of substituted pyridines and isatins with methyl propiolate, or dimethyl acetylenedicarboxylate. The stereochemistry of the products was clearly clarified by the analysis of 1 H NMR data and single crystal structures of the obtained polycyclic compounds.