“…The first is the synthesis of fluorinated chalcone through Claisen-Schmidt condensation, then the second is the synthesis of fluorinated pyrazoline through intermolecular cyclization of fluorinated chalcone with a hydrazine or its derivatives [7] such as thiosemicarbazide [4], phenylhydrazine [8], hydrazine hydrate [9], halogenated phenylhydrazine [10], and 3,4,5-trimethoxybenzohydrazide [11]. Other researchers have also reported one-pot synthesis of pyrazolines from various starting materials and methods such as from 3-butynol and substituted phenylhydrazine under reflux condition [12], from substituted acetophenone, benzaldehyde, and phenylhydrazine under reflux condition [13,14] and through the formal [4 + 1] annulation reaction of 3-bromooxindoles and in situ-derived 1,2-diaza-1,3-dienes by stirring at room temperature [15]. In addition, it has also been reported that the one-pot synthesis of pyrazolines can be performed by reacting pyridine based chalcone and hydrazine hydrate under 300 W microwave irradiation [16]; by reacting substituted chalcone, hydrazine hydrate, and acetic anhydride under 550 W microwave irradiation [17]; and by reacting substituted pyrazole, formaldehyde, and β-diketone under 300 W microwave irradiation [18].…”