One‐pot Three Component Synthesis of ω‐(oxathiolan‐2‐thion‐5‐yl)‐α‐oxazolidin‐2‐ones

Abstract

We report a practical and one‐pot synthesis of novel series of ω‐(oxathiolan‐2‐thione‐5‐yl)‐α‐ oxazolidin‐2‐ones (3a‐h). The obtained compounds have been designed, synthesized via reaction of oligoethylene glycols diglycidyl ethers, isocyanate and carbon disulfide in the presence of catalytic amount of lithium bromide. A variety of important oxazolidinone derivatives can be obtained from simple starting materials in good yields and the biological activity of these new products will be investigated in complementary study.

Synthesis, Molecular Docking, and Bioactivity Study of Novel Hybrid Benzimidazole Urea Derivatives: A Promising α-Amylase and α-Glucosidase Inhibitor Candidate with Antioxidant Activity

“…The discovery of new α-glucosidase and α-amylase inhibitor agents is an interesting method of obtaining such drugs. To contribute to the advancement of the design and the discovery of new bioactive species [ 66 , 67 , 68 , 69 , 70 , 71 ], we combined the two patterns, benzimidazole and urea, in the same molecule, allowing for potential antidiabetic agents, and having good anti-oxidant activity.…”

Design, Synthesis, Characterization and Anticancer Evaluation of Novel Mixed Complexes Derived from 2-(1H-Benzimizadol-2-yl)aniline Schiff base and 2-Mercaptobenzimidazole or 2-Aminobenzothiazole

“…In continuation to develop and discover a novel molecular architecture possessing biological activities [43][44][45][46][47][48], we report the synthesis and anti-cancer evaluation of new mixed metal copper complexes derived from 2-aminomethylbenzothiazole, 2aminomethylbenzothiazole and Schiff base of 2-(1Hbenzimizadol-2-yl)aniline as ligand.…”