One-pot three-component synthesis and photophysical properties of highly fluorescent novel 4-alkyl-3-aryl-2,6-dicyanoanilines by using tris(hydroxymethyl)aminomethane as a catalyst

In-depth Photo-physical Properties, Characterization and Cell Imaging Applications of 2, 6-dicyanoanilines Based on Iso-phthalaldehyde and Tere-phthalaldehyde Frame

“…The plausible mechanism [4] of the reaction which yields two acceptor-donor-acceptor features on single aromatic ring is depicted in Scheme 4. Initially, base catalyzed knoevenagel reaction of aromatic aldehyde and aliphatic aldehyde with malononitrile yields respective knoevenagel products (I).…”

“…The 2,6-dicyanoanilines and their analogues are known for their significant fluorescent properties [3,4] and have been studied and exploited in many different areas of science like nonlinear optical materials [5,6,7], molecular electronic devices [8] and have been reported to exhibit biological activities like antileishmanial [8], inhibitor of a-amylase and a-glucosidase enzymes [9], and antifungal [10] activity. "Also, the flexibility of conversion of cyano and amino groups in to other functional groups makes these compounds versatile for utilization as intermediates in the preparation of many diverse substrates for comprehensive use".…”

Substituent-Dependent Divergent Synthesis of 2-(3-Amino-2,4-dicyanophenyl)pyrroles, Pyrrolyldienols and 3-Amino-1-acylethylidene-2-cyanopyrrolizines via Reaction of Acylethynylpyrroles with Malononitrile

“…At the same time, the compounds containing 2,6-dicyanoaniline scaffold exhibit various biological activities [ 53 , 54 , 55 ], strong fluorescence [ 55 , 56 , 57 , 58 , 59 ] and may be used as nonlinear optical materials [ 55 , 60 , 61 ] and cell imaging agents [ 55 , 62 ] ( Figure 1 ). Furthermore, they serve as building blocks for the synthesis of diverse biologically active compounds and a large number of heterocyclic derivatives, including indoles, quinazolines, fluorenones, indazoles, benzoxazines and benzotriazinones [ 55 ].…”

Synthesis and Characterization of Graphitic Carbon Nitride Supported Tris(Hydroxymethyl)Aminomethanem) G-C3N4/ THAM) as Novel Catalyst for the Synthesis of Poly Hydroquinoline and Pyranopyrazole Derivatives

“…The THAM molecule particular structure enriches it with donoracceptor groups 16 .This structure is a creative and very interesting combination that broadly used in molecular biology, biochemistry and chemistry 17,18 . One of the things that has attracted the attention of chemists to this molecule is its non-toxicity, cost-effectiveness, degradability and biocompatibility of the compound 19 .…”