One-pot, three-component reaction of isocyanides, dialkyl acetylenedicarboxylates, and non-cyclic anhydrides: synthesis of 2,5-diaminofuran derivatives and dialkyl (E)-2-[(N-acyl-N-alkylamino)carbonyl]-2-butenedioates

In situ generation and protonation of the isocyanide/acetylene adduct: a powerful catalyst-free strategy for multicomponent synthesis of ketenimines, aza-dienes, and heterocycles

“…63 Bayat and co-workers could also synthesize both 103 and 104 products from the reaction of 1 and 2 with anhydrides. 64 A simple synthesis of uracil based aminofurans 106 via an IAMCR method was reported by Baharfar and Baghbanian. 65 The reaction was achieved with fairly good yields (Scheme 32).…”

One-pot synthesis of α-hydroxyamides using alkyl isocyanides and aryl aldehydes

“…As part of our current studies on the development of new routes to the synthesis of organic compounds and our interest in isocyanide-based reactions [16,17], we planned to test the reaction between isocyanides and CS 2 in the presence of aryl aldehydes in CH 2 Cl 2 (Scheme 1).…”

Four-Component Synthesis of 2-(N,N-Dialkylamino)-2,4,6-Cycloheptatrien-1-One Derivatives from Tropolone, an Isocyanide, a Primary Amine and an Aldehyde via Ugi-Smiles Coupling Reaction

“…Therefore, MCRs have attracted much attention because of their exceptional synthetic applications. [2][3][4][5] Since all the organic reactants employed are used and moved toward the target compound so purification of products resulting from MCRs is simple. 6,7 Isocyanide-based multicomponent reactions (abbreviated to IMCRs by Ugi and Dömling) have an interesting position.…”