One-Pot Template-Free Fabrication of Hollow Magnetite Nanospheres and Their Application as Potential Drug Carriers

Liu, Shanhu; Xing, Ruimin; Lu, Feng; Rana, Rohit Kumar; Zhu, Jun‐Jie

doi:10.1021/jp907296n

Cited by 125 publications

(80 citation statements)

References 40 publications

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“…Figure 2 C showed that the lattice fringes were 0.253 nm, in good agreement with the values for {311} planes of cubic magnetite phase; and the same crystal orientation of different magnetite crystallites was observed. [26] The selected-area electron diffraction (SAED) pattern recorded on a single Figure S1B in the Supporting Information). Therefore, it could be concluded that each octahedron was a single crystal enclosed by eight {111} planes.…”

Section: Resultsmentioning

confidence: 99%

Structural Effects of Fe₃O₄ Nanocrystals on Peroxidase‐Like Activity

Liu

Xing

et al. 2010

Chemistry A European J

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240

109

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The catalytic activity of nanocrystal catalysts depends strongly on their structures. Herein, we report three distinct structures of Fe(3)O(4) nanocrystals, cluster spheres, octahedra, and triangular plates, prepared by a similar hydrothermal procedure. Additionally, the three Fe(3)O(4) nanostructures were used as peroxidase nanomimetics and the correlation between the catalytic activities and the structures was first explored by using 3,3',5,5'-tetramethylbenzidine and H(2)O(2) as peroxidase substrates. The results showed that the peroxidase-like activities of the Fe(3)O(4) nanocrystals were structure dependent and followed the order cluster spheres>triangular plates>octahedra; this order was closely related to their preferential exposure of catalytically active iron atoms or crystal planes. Such investigation is of great significance for peroxidase nanomimetics with enhanced activity and utilization.

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Section: Resultsmentioning

confidence: 99%

Structural Effects of Fe₃O₄ Nanocrystals on Peroxidase‐Like Activity

Liu

Xing

et al. 2010

Chemistry A European J

Self Cite

240

109

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“…80,[92][93][94] Li et al synthesized an HMCNC-based Dox-loaded nanomedicine with porous shell and tunable hollow chamber by a one-pot solvothermal process. 81 This HMCNC carrier had a high surface area of 41.2 m 2 /g and pore volume of 0.36 cm 3 /g, which contributed to high drugloading capacity.…”

Section: Mesoporous Magnetic Colloidal Nanocrystal Clustersmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

419

268

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Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

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“…The maximum loading capacity was calculated to be 8 μg of R6G on 140 μg of starch-GNS. Compared to other reported materials [23][24], this higher loading capacity was attributed to the large specific surface area of starch-GNS and the strong - conjugation as well as hydrogen bonding interaction between starch-GNS and R6G.…”

Section: Page 13 Of 30mentioning

confidence: 60%