One-pot synthesis of theranostic nanocapsules with lanthanide doped nanoparticles

Abstract

<p>One-pot synthesis of theranostic nanocapsules with lanthanide doped nanoparticles <italic>via</italic> interfacial templating condensation for upconversion based photodynamic therapy.</p>

Phytoglycogen Encapsulation of Lanthanide‐Based Nanoparticles as an Optical Imaging Platform with Therapeutic Potential

“…The higher efficiency of NIR‐excited PDT when compared to direct excitation of a photosensitizer has been previously reported in the literature and was ascribed to reduced scattering and deeper penetration depth of the NIR irradiation when compared to UV–vis light necessary for direct excitation. [ 10,34 ]…”

“…The higher efficiency of NIR-excited PDT when compared to direct excitation of a photosensitizer has been previously reported in the literature and was ascribed to reduced scattering and deeper penetration depth of the NIR irradiation when compared to UV-vis light necessary for direct excitation. [10,34] Encouraged by the results of NIR-induced ROS generation by UCNP-1/Ce6-PGLY, the beads' capability to act as PDT agent was assessed in vitro, using A549 human lung adenocarcinoma cells (Figure 4). Upon NIR irradiation for 20 min (P 980 = 1.6 W cm -2 ), the ROS generated by UCNP-1/Ce6-PGLY led to decrease in cell viability when compared to control samples kept in the dark (Figure S14, Supporting Information), as observed by live/dead staining (Figure 4B) and cell counting (Figure 4C).…”

“…[9] Recently, emulsion-based approaches have also been extended to the surface functionalization of hydrophobic nanoparticles, in particular to lanthanide (Ln)-doped upconverting nano particles (UCNPs) of the general family MLnF 4 (M = alkali metal, such as Li, Na, K). [10][11][12][13] UCNPs are attractive materials due to the breadth of their potential applications ranging from imaging platforms [14,15] and energy donors in Förster resonance energy transfer (FRET) pairs [16][17][18][19] to light-triggered therapies, [11,13,20,21] among others. [22][23][24] However, synthesis of high-quality UCNPs is most commonly performed in a hydrophobic environment, generating samples that are not water-dispersible.…”

“…[36][37] For example, PS chemically bound to surface-functionalized UCNPs or loaded into porous silica/polymeric shells have been reported as successful PDT agents. [10,13,[33][34]39] Still, given the hydrophobic character of most PS molecules, there is room for improvement in systems for PS delivery to the treatment site in the biological environment. [40] To overcome this drawback, liposomes and polyethylene glycol (PEG)-phospholipids were used for the encapsulation of UCNPs.…”

An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

“…Short wavelength light absorbed by PSs cannot reach deep tissue due to absorption of skin and subcutaneous adipose tissue, resulting in lower photoconversion, serious tissue damage and limited clinical application of PDT in deep tumors. 3 To address this issue, some strategies such as the two-photon excitation (TPE) technique 4,5 and upconversion nanoparticles (UCNPs) 6,7 had been introduced for the therapy of deep tumors, but their complex equipment and their low conversion efficiency will bring about new problems for clinical applications. 8,9 Thus, PSs with strong NIR (700–1000 nm) absorption, which display deeper tissue penetration and minimized photodamage, have attracted intense research efforts for eradicating tumors in deep sites.…”