One-pot synthesis of superabsorbent hybrid hydrogels based on methacrylamide gelatin and polyacrylamide. Effortless control of hydrogel properties through composition design

Serafim, Andrada; Țucureanu, Cătălin; Petre, Daniela-Geta; Drăgușin, Diana-Maria; Sălăgeanu, Aurora; Vlierberghe, Sandra Van; Dubruel, Peter; Stancu, Izabela‐Cristina

doi:10.1039/c4nj00161c

Cited by 67 publications

(61 citation statements)

References 34 publications

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“…In another study, Serafim et al . characterized a family of hybrid hydrogels made from GelMA and polyacrylamide (PAA) by a simple “one-pot” synthesis using photopolymerization [17]. The authors presented a correlation between composition and hybrid PAA-GelMA properties relevant to tissue culture and drug delivery applications, such as swelling, mechanical properties, porosity of the resulting covalent PAA-GelMA network, and biodegradability [17].…”

Section: Hybrid Hydrogels Based On Gelmamentioning

confidence: 99%

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

et al. 2015

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Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics. Three dimensional (3D) GelMA hydrogels closely resemble some essential properties of native extracellular matrix (ECM) due to the presence of cell-attaching and matrix metalloproteinase responsive peptide motifs, which allow cells to proliferate and spread in GelMA-based scaffolds. GelMA is also versatile from a processing perspective. It crosslinks when exposed to light irradiation to form hydrogels with tunable mechanical properties which mimic the native ECM. It can also be microfabricated using different methodologies including micromolding, photomasking, bioprinting, self-assembly, and microfluidic techniques to generate constructs with controlled architectures. Hybrid hydrogel systems can also be formed by mixing GelMA with nanoparticles such as carbon nanotubes and graphene oxide, and other polymers to form networks with desired combined properties and characteristics for specific biological applications. Recent research has demonstrated the proficiency of GelMA-based hydrogels in a wide range of applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others. Other applications of GelMA hydrogels, besides tissue engineering, include fundamental single-single cell research, cell signaling, drug and gene delivery, and bio-sensing.

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Section: Hybrid Hydrogels Based On Gelmamentioning

confidence: 99%

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

et al. 2015

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“…For instance, GelMA/polyacrylamide hybrid hydrogel has been used to control the release of sodium nafcilin monohydrate, an antibiotic against Staphylococcus sp. bacteria [93]. Moreover, by integrating a dielectrophoresis system with gold microparticle-laden GelMA hydrogels, the controlled release of drugs was achieved with a concentration gradient for high-throughput drug screening applications [34].…”

Section: Synthesis Properties and Recent Biomedical Applications Of Phmentioning

confidence: 99%

Recent Advances in Photo-Crosslinkable Hydrogels for Biomedical Applications

et al. 2019

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Photo-crosslinkable hydrogels have recently attracted significant scientific interest. Their properties can be manipulated in a spatiotemporal manner through exposure to light to achieve the desirable functionality for various biomedical applications. This review article discusses the recent advances of the most common photo-crosslinkable hydrogels, including poly(ethylene glycol) diacrylate, gelatin methacryloyl and methacrylated hyaluronic acid, for various biomedical applications. We first highlight the advantages of photopolymerization and discuss diverse photosensitive systems used for the synthesis of photo-crosslinkable hydrogels. We then introduce their synthesis methods and review their latest state of development in biomedical applications, including tissue engineering and regenerative medicine, drug delivery, cancer therapies and biosensing. Lastly, the existing challenges and future perspectives of engineering photo-crosslinkable hydrogels for biomedical applications are briefly discussed.

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“…Xu et al 25 developed GelMA/PAM hybrid hydrogels with low GelMA content as a cell template to generate 3D cell spheroids, however, the mechanical properties and bioactivity of the hydrogels are not well illustrated. Stancu et al 26 investigated the mechanical properties of the GelMA/PAM hybrid hydrogels and also biocompatibility of the hydrogels. Those previous results indicate that the hybridization of synthetic and natural polymers is able to form hydrogels with desirable molecular architectures, chemical compositions, mechanical properties and biological functions for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Biohybrid methacrylated gelatin/polyacrylamide hydrogels for cartilage repair

Han

et al. 2017

J. Mater. Chem. B

138

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Articular cartilage defect repair is challenging for clinics because it is avascular tissue lack of self-regenerative ability. Gelatin-based hydrogels are widely used in the field of tissue engineering because of their good biodegradability, excellent biocompatibility, and cell/tissue affinity. However, gelatin-based hydrogels exhibit poor thermal stability and low mechanical strength, which limits their applications in cartilage repair. In this study, methacrylic anhydride (MA) was employed to modify gelatin to obtain photo-crosslinkable methacrylated gelatin (GelMA). The GelMA-based natural-synthetic polymer biohybrid hydrogel was prepared by co-polymerizing acrylamide (AM) and GelMA under ultraviolet radiation in the presence of a photo-initiator. The GelMA/PAM biohybrid hydrogel simultaneously possessed the advantages of both PAM hydrogels and GelMA hydrogels. The GelMA block provided specific biological functions for cell adhesion and proliferation, while the flexible PAM chains reinforced the brittle gelatin network and sustain load during deformation. Compared with pure PAM hydrogel and GelMA, the GelMA/PAM biohybrid hydrogels showed enhanced compression strength (0.38 MPa) and improved elasticity (storage modulus of 1000 Pa). The GelMA/PAM biohybrid hydrogel showed a favorable degradation rate and sustained protein release. In vitro cell culture showed that the chondrocytes remained viable and proliferated on the biohybrid hydrogel, demonstrating that the biohybrid hydrogels had good cell adhesion and excellent biocompatibility. In a rabbit knee cartilage defect model, we evaluated the cartilage repair ability of the biohybrid hydrogel in vivo. In summary, this study demonstrated that hybridization of synthetic polymers considerably improves the performance and expands the application of the gelatin-based hydrogels. The biohybrid

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One-pot synthesis of superabsorbent hybrid hydrogels based on methacrylamide gelatin and polyacrylamide. Effortless control of hydrogel properties through composition design

Abstract: Network-forming polymerization of methacrylamide gelatin and acrylamide generates scaffolds with controlled biocompatibility and water affinity.

Cited by 67 publications

References 34 publications

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

Recent Advances in Photo-Crosslinkable Hydrogels for Biomedical Applications

Biohybrid methacrylated gelatin/polyacrylamide hydrogels for cartilage repair

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