One-pot synthesis of self-assembled heteroleptic palladium(II) complexes with tmeda: An application of ligand exchange reactions

Bandi, Sreenivasulu; Debata, Niladri Bihari; Ramkumar, V.; Chand, Dillip Kumar

doi:10.1016/j.inoche.2013.10.047

Cited by 10 publications

(6 citation statements)

References 30 publications

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“…We established a type of reorganization reaction that relates a given Pd x L′ x L y -type complex (where L′ stands for en) with a mixture of corresponding Pd m L n and PdL′ 2 -type complexes. ,,− When a solution of [Pd x (en) x (L) y ](NO 3 ) 2 x in DMSO is heated, we observed two situations, wherein either partial or complete transformation of the starting complex to generate corresponding [Pd m (L) n ](NO 3 ) 2 m -type complex and concomitant [Pd(en) 2 ](NO 3 ) 2 , 6 at 1: m ratios occurred as shown in eqs 4 and 5 (Scheme ), respectively. Subsequently, similar transformations of a [Pd 3 (en) 3 (L) 2 ](NO 3 ) 6 system was also observed by Hardie et al…”

Section: Results and Discussionmentioning

confidence: 99%

“…We experienced that interaction of [Pd m (L) n ](NO 3 ) 2m with [Pd(tmeda) 2 ](NO 3 ) 2 allows a rearrangement leading to [Pd x (tmeda) x (L) y ](NO 3 ) 2x . 58 Accordingly, addition of double quantity of the required amount of the stimuli (e.g., 7), either in one go (eq 7 of Scheme 4) or in two portions, were considered to demonstrate an unprecedented transformation where the starting complex [Pd x (en) x (L) y ](NO 3 ) 2x could be possibly transformed to [Pd x (tmeda) x (L) y ](NO 3 ) 2x . Such transformations remained successful as per the anticipation.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The residual peak of DMSO- d 6 signal is calibrated at 3.04 ppm with respect to tetramethylsilane (TMS) in CDCl 3 as external standard (Supporting Information Figure S77). The cis-protected palladium(II) components and the ligand L were prepared following known procedures. − The complexes [Pd 2 (en) 2 ( L ) 2 ](NO 3 ) 4 , 1 ; [Pd(en) 2 ](NO 3 ) 2 , 6 ; [Pd(tmeda) 2 ](NO 3 ) 2 , 7 ; [Pd(bpy) 2 ](NO 3 ) 2 , 8 ; [Pd(phen) 2 ](NO 3 ) 2 , 9 ; and [Pd(en)(bpy)](NO 3 ) 2 , 11 are reported, − whereas other complexes ( 2 , 3 , 4 , 5 , 10 , and 12 ) are new. However, the synthesis of 1 – 5 and 9 – 12 is described below.…”

Section: Methodsmentioning

confidence: 99%

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Molecular Recombination Phenomena in Palladium(II)-Based Self-Assembled Complexes

Ganta

Chand

2018

Inorg. Chem.

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A series of self-assembled binuclear complexes (1-4) of PdL'L composition are prepared by combination of selected cis-protected palladium(II) component cis-PdL' with equimolar amount of the nonchelating bidentate ligand 1,3-bis((pyridine-4-yl)methyl)urea, L. The cis-protecting unit L' crafted in the complexes [Pd(L')(L)](NO), 1-4, are ethylenediamine (en), tetramethylethylenediamine (tmeda), 2,2'-bipyridine (bpy), and 1,10-phenanthroline (phen), respectively. Complexation of palladium(II) with the ligand L, however, resulted in the self-assembled trinuclear complex [Pd(L)](NO), 5, of PdL composition. A few other mononuclear complexes relevant to this work are the homoleptic (6-9) and the heteroleptic (10-12) of PdL' composition, where the term L' in the formula stands for en, tmeda, bpy, and phen. The two units of L' in the complexes 6-12 are en-en, tmeda-tmeda, bpy-bpy, phen-phen, en-tmeda, en-bpy, and en-phen, respectively. Keeping in mind the recombination of fragments in biomolecular systems, it was considered to study the recombination of fragments among assorted self-assembled coordination complexes. In this context, the complexes 1-12 are employed. The recombination was planned on the basis of information already coded in the complexes that we realized from our experience. Designated complexes from this list are subjected to deliberate circumstances, whereupon remarkable "molecular recombination" processes ensued. For instance, combination of [Pd(en)(L)](NO), 1 with [Pd(tmeda)](NO), 7 at 1:2 molar ratio produced [Pd(tmeda)(L)](NO), 2 and concomitant [Pd(en)(tmeda)](NO), 10 at 1:2 molar ratio. A number of reorganization reactions are studied through selective combinations of two types of complexes from the pool of 1-12. The detailed finding is described in the article so as to conceptualize molecular recombination and other related dynamic processes in self-assembled coordination complexes of a chosen family. Crystal structures of a few complexes (2, 4, and 5) and intermolecular interactions in the crystal packing with particular reference to π-π interactions in 4 are also discussed.

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Section: Results and Discussionmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Molecular Recombination Phenomena in Palladium(II)-Based Self-Assembled Complexes

Ganta

Chand

2018

Inorg. Chem.

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“…Several ligands of this type were studied but crystalline complexes suitable for X-ray structure determination were obtained only with the ligands LL = 2 -4 (Chart 1). The related ligands 2 [23][24][25][26][27][28][29][30][31][32][33] and 3 [24,26,28,30,33,[34][35][36][37][38][39][40][41], which contain 4-pyridyl and 3-pyridyl groups respectively, are angular whereas ligand 4 [42][43][44][45][46][47][48][49][50][51] is more linear, though it should be recognized that all of these ligands are flexible and can adapt to several different coordination geometries.…”

Section: 1mentioning

confidence: 99%

Complexes of gold(I) with a chiral diphosphine and bis(pyridine) ligands: Isomeric macrocycles and a polymer

Wheaton

Puddephatt

2016

Polyhedron

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“…[38] Research in this regard has led to the recent development of different binary [39,40] and heteroleptic [41] metal complexes of COC exhibiting anticancer activity. This work describes the synthesis of new nanosized heteroleptic d-block complexes of COC using N,N,N 0 ,N 0tetramethylethane-1,2-diamine (TMEDA, Figure 1b) [42] as a coligand, which has been extensively utilized for metal complexation because of its high potential to improve the chelation rate of aromatic systems and the regiochemistry of these reactions [43][44][45][46][47] and the investigation of their cytotoxic activities against HepG-2 and MCF-7 cancer cell lines and their antibacterial and antifungal activities. The prepared complexes were structurally characterized using elemental analysis, molar conductivity, ultraviolet-visible (UV-vis), Fourier transform infrared (FTIR), and energy-dispersive X-ray (EDX) spectroscopies, and mass spectrometry.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural characterization, density functional theory calculations, and antimicrobial, anticancer, and antimetastatic properties of nanosized heteroleptic complexes of cocaine/TMEDA with d‐block metal ions

Abdallah

Zaki

Mahmoud

et al. 2021

Applied Organom Chemis

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In the field of transition metal chemistry, the development of transition metal‐based drugs for the treatment of diseases such as cancer or microbial infections with minimization of adverse effects and drug resistance constitutes an active area of research. Herein, eight novel nanosized heteroleptic complexes of cocaine/TMEDA with the formula [M(COC)(TMEDA)Cly(OH2)z]nCl·xH2O (M = Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II); COC = cocaine; TMEDA = N,N,N′,N′‐tetramethylethylenediamine, y = 1–2; z = 0–1; n = 0–1; and x = 0–2) were synthesized and structurally characterized via elemental analysis, molar conductivity, mass spectrometry, and spectroscopic and microscopic techniques. The thermal properties and kinetic thermodynamic parameters of the synthesized complexes were also studied. The geometry and electronic structures were investigated via density functional theory (DFT) calculations. The antiproliferative activity of the complexes on HepG‐2 and MCF‐7 cancer cell lines was quantified via MTT assay. The Fe(III) and Cd(II) complexes exhibited promising cytotoxic activities against the HepG‐2 and MCF‐7 cancer cell lines, respectively, with minimum effect on HFB4 human normal cells. Further molecular mechanistic studies were performed on the Cd(II) complex to inspect its influence on different cancer pathophysiology‐related processes in the MCF‐7 cell line including metastasis, apoptosis, and cellular oxidative stress and on the cellular levels of the human tumor suppressor nuclear proteins p21 and p27. The results revealed that the Cd(II) complex is a promising anticancer agent that acts through several molecular mechanisms with minimum effect on the normal cells and with additional antimetastatic properties. Furthermore, the antibacterial and antifungal activities of the prepared complexes were investigated.

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One-pot synthesis of self-assembled heteroleptic palladium(II) complexes with tmeda: An application of ligand exchange reactions

Cited by 10 publications

References 30 publications

Molecular Recombination Phenomena in Palladium(II)-Based Self-Assembled Complexes

Molecular Recombination Phenomena in Palladium(II)-Based Self-Assembled Complexes

Complexes of gold(I) with a chiral diphosphine and bis(pyridine) ligands: Isomeric macrocycles and a polymer

Synthesis, structural characterization, density functional theory calculations, and antimicrobial, anticancer, and antimetastatic properties of nanosized heteroleptic complexes of cocaine/TMEDA with d‐block metal ions

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