One-pot synthesis of PLA-b-PHEA via sequential ROP and RAFT polymerizations

Abstract

A block copolymer library of polylactide and poly(2-hydroxyethyl acrylate) was prepared via sequential ring opening polymerization and RAFT polymerization in a one-pot approach.

Synthesis of amphiphilic block copolymers via ring opening polymerization and reversible addition‐fragmentation chain transfer polymerization

“…For example, 2-hydroxyethyl methacrylate, 2-methacryloyloxyethyl phosphorylcholine, 2-(dimethylamino)ethyl methacrylate and other hydrophilic methacrylates and acrylates, as well as acrylamides such as N-(2-hydroxypropyl) methacrylamide and Nisopropylacrylamide (NIPAM) have been used. 39,[41][42][43][44][45][46][47][48][49] Similarly, macromonomers such as oligo(ethylene glycol) methacrylate (OEGMA) have been studied. 43,44,50,51 As non-linear PEG-analogs, poly(OEGMA)-based materials show high biocompatibility, and due to their thermoresponsive behavior have emerged as alternatives to poly(NIPAM).…”

Electrosprayed cysteine-functionalized degradable amphiphilic block copolymer microparticles for low pH-triggered drug delivery

“…12 Also, incorporation of functional groups in PLA structure can be challenging since these are often not tolerated in the ring opening polymerization (ROP) 13,14 methodology that is used for its synthesis. By using a more versatile polymerization technique, such as reversible addition-fragmentation chain transfer (RAFT) polymerization, 15,16 in combination with ROP, [17][18][19][20][21][22][23][24][25][26][27] for the synthesis of the hydrophilic block of a PLA-based amphiphilic block copolymer, different functional groups can be incorporated in the polymer. These functional groups can give interesting properties to the amphiphilic block copolymer.…”

“…Several researchers have overcome issues in synthesizing block copolymers by combining these two polymerization techniques in one pot by using a dual reagent that can initiate both techniques. [19][20][21][22][23][24][25][26][27] These polymerizations can take place either as a single reaction, where both polymerizations are taking place simultaneously, 19,[22][23][24]27 or as sequential reactions, [20][21][22]25,26 in cases where the polymerizations require different conditions.…”

Direct Metal‐Free Preparation of Functionalizable Polylactic Acid‐Ethisterone Conjugates in a One‐Pot Approach

“…Polyesters are one of the most widely used biodegradable materials . Moreover, polylactic acid (PLA) represents a biocompatible, nontoxic, and biorenewable polymer, it offers diverse and potent fields of application particularly in biomedical and pharmaceutical areas, such as the production of resorbable sutures, bioabsorbable implants for bone fixation, scaffolds for tissue engineering, and carriers for controlled drug release systems …”