One-pot synthesis of PDMAEMA-bound iron oxide nanoparticles for magnetofection

Huang, Shih-Jer; Ke, Jyun-Han; Chen, Guojing; Wang, Li Fang

doi:10.1039/c3tb21149e

Cited by 30 publications

(16 citation statements)

References 31 publications

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“…43 Whilst in this study an excess of PLL was left after conjugation with the IONPs, Ju et al demonstrated that extra washing procedures can be used to wash away any ''free'' PLL not associated with IONPs, thus lowering the overall PLL to iron oxide ratio, whilst maintaining ''safe'' uptake into human umbilical MSCs of up to 65 pg[Fe] per cell. 45 PEI is a polymer containing primary amines that has been shown to have transfection efficiency at a molecular weight of 25 kDa.…”

Section: Other Charged Polymersmentioning

confidence: 99%

Design considerations for the synthesis of polymer coated iron oxide nanoparticles for stem cell labelling and tracking using MRI

et al. 2015

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Iron oxide nanoparticles (IONPs, sometimes called superparamagnetic iron oxide nanoparticles or SPIONs) have already shown promising results for in vivo cell tracking using magnetic resonance imaging (MRI). To fully exploit the potential of these materials as contrast agents, there is still a need for a greater understanding of how they react to physiological conditions. A key aspect is the specific nature of the surface coating, which can affect important properties of the IONPs such as colloidal stability, toxicity, magnetism and labelling efficiency. Polymers are widely used as coatings for IONPs as they can increase colloidal stability in hydrophilic conditions, as well as protect the iron oxide core from degradation. In this tutorial review, we will examine the design and synthesis approaches currently being employed to produce polymer coated IONPs as cell tracking agents, and what considerations must be made. We will also give some perspective on the challenges and limitations that remain for polymer coated IONPs as MRI contrast agents for stem cell tracking.

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Section: Other Charged Polymersmentioning

confidence: 99%

Design considerations for the synthesis of polymer coated iron oxide nanoparticles for stem cell labelling and tracking using MRI

et al. 2015

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“…5d). 12,31,38,[44][45][46][47][48][49] Nevertheless, the prepared LP displayed a mechanical strength that surpassed that of cancellous bone. It also showed a better elastic modulus than that synthetic MTT/CNF composites.…”

Section: Resultsmentioning

confidence: 96%

Synthesis of self-assembled nacre-like materials with 3D periodic layers from nanochitin via hydrogelation and mineralization

Liu

et al. 2021

Preprint

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Here introduced a route for the synthesis of 3D structures that display a mechanical strength that competes with that of the toughest materials found in nature. Following the “brick-and-mortar” biomineralization typical of nacre, self-stratified, periodic materials are obtained by one-step ion diffusion gradient and hydrogelation of nanochitin with simultaneous mineral coprecipitation. Specifically, under appropriate electrolyte conditions, hydroxyapatite (HA) microspheres grow in an organic network formed from partially deacetylated chitin nanofibers (NCh), resulting in periodic stacking of mineralized (HA) and non-mineralized (NCh) layers. By directional diffusion, customizable 3D shapes are self-assembled and demonstrated to function as optical waveguides with selective light transmission at interfaces. Upon hot pressing, the resulting solid structures exhibit a superb mechanical performance while being biocompatible (tested with chondrogenic ATDC5 cells as a model for physiological mineralization). Overall, a shape-controlled, one-pot biomineralization method was proposed that achieves hierarchical, periodic and strong “nacre-like” structures suitable as biomedical material.

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“…Rh6G dye Temperature P(OEGMA-co-MEO2MA) SWCNTs [96] Rh6G dye Temperature PNIPAAm-co-PAAm Au nanocage [97] Rh6G dye pH PDMAEMA MSNs [98] RhB dye pH PDEAEMA MSNs [99] Dye (Calcein) pH P4VP MSNs [ 100] Diol derivatives Saccharide and temperature PNIPAAm-co-PMAA AuNSs [ Doxorubicin, lysozyme Temperature PNIPAAm-co-PAAm Au nanocage [ 116] plasmid DNA pH and temperature PDMAEMA SPIONs [ 117] plasmid DNA pH PDMAEMA SPIONs [ 118] CPT, plasmid DNA pH PDMAEMA GO [ 119] plasmid DNA pH PDMAEMA LDHs [ 120] plasmid DNA pH PDMAEMA Chiral Si nanorods [ 121] plasmid DNA Shielding effect PDMAEMA Spindly CNCs [ 122] siRNA Bioreductivity Poly(DAMA-HEMA) Gold NPs [40] plasmid DNA pH PDMAEMA Silica NPs [36] plasmid DNA, siRNA pH PDMAEMA Silica NPs [95] siRNA pH PDMAEMA Silica NPs [18] siRNA pH PDMAEMA Silica NPs [39] plasmid DNA pH PDMAEMA Nanodiamond (with bioimaging) [ 123] siRNA pH PDMAEMA UCNPs (with phototherapy) [ 124] siPD-L1 Redox SPDP Magnetic nanoparticle (MRI imaging) [ 125] siPD-L1 Redox FA-PEG-SS-PEI SPION (MRI imaging) Applications of responsive polymer brushes for triggered drug delivery. A) PDEAEMA-coated silica nanoparticles and pH-sensitive controlled release of a model dye.…”

Section: Triggered Drug Delivery and Therapymentioning

confidence: 99%

Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics

Wang

et al. 2020

Adv Healthcare Materials

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Responsive polymer brushes are a category of polymer brushes that are capable of conformational and chemical changes in response to external stimuli. They offer unique opportunities for the control of bio−nano interactions due to the precise control of chemical and structural parameters such as the brush thickness, density, chemistry, and architecture. The design of responsive brushes at the surface of nanomaterials for theranostic applications has developed rapidly. These coatings can be generated from a very broad range of nanomaterials, without compromising their physical, photophysical, and imaging properties. Although the use of responsive brushes for nanotheranostic remains in its early stages, in this review, the aim is to present how the systems developed to date can be combined to control sensing, imaging, and controlled delivery of therapeutics. The recent developments for such design and associated methods for the synthesis of responsive brushes are discussed. The responsive behaviors of homo polymer brushes and brushes with more complex architectures are briefly reviewed, before the applications of responsive brushes as smart delivery systems are discussed. Finally, the recent work is summarized on the use of responsive polymer brushes as novel biosensors and diagnostic tools for the detection of analytes and biomarkers.

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One-pot synthesis of PDMAEMA-bound iron oxide nanoparticles for magnetofection

Cited by 30 publications

References 31 publications

Design considerations for the synthesis of polymer coated iron oxide nanoparticles for stem cell labelling and tracking using MRI

Design considerations for the synthesis of polymer coated iron oxide nanoparticles for stem cell labelling and tracking using MRI

Synthesis of self-assembled nacre-like materials with 3D periodic layers from nanochitin via hydrogelation and mineralization

Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics

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