Abstract:Reaction of 4-amino-4H-1,2,4-triazole-3,5-dithiol 1a with hydrazonoyl halides 2 in ethanol in the presence of sodium ethoxide under reflux led to the formation of the title compounds 5. The latter products can also obtained by reaction of 4-amino-3,5-di(methylthio)-4H-1,2,4-triazole 1b with hydrazonoyl halides 2 in ethanol in the presence of sodium ethoxide by stirring over night at room temperature. The structures of the products were evidenced by spectral, elemental as well as X-ray diffraction analyses. The… Show more
“…Elemental analyses were carried out at the Microanalytical Centre of Cairo University. The hydrazonoyl halides 1A , 1B , 1C were prepared following literature procedures .…”
New bis(pyrazolylenaminones) were prepared in good yields. Their synthetic utilities as precursors for regioselective synthesis of novel bis(hetarylpyrazoles) were also investigated. The mechanisms and selectivities observed in the studied reactions were discussed.
“…Elemental analyses were carried out at the Microanalytical Centre of Cairo University. The hydrazonoyl halides 1A , 1B , 1C were prepared following literature procedures .…”
New bis(pyrazolylenaminones) were prepared in good yields. Their synthetic utilities as precursors for regioselective synthesis of novel bis(hetarylpyrazoles) were also investigated. The mechanisms and selectivities observed in the studied reactions were discussed.
Other 6-membered heterocycles R 0670One-Pot Synthesis of Novel 1,2,3,4,5a,7,8,8b-Octaaza-acenaphthylenes (III). -(SHAWALI*, A. S.; MOSSELHI, M. A. N.; ABDALLAH, M. A.; ELEWA, M. S.; J. Chem.
3‐Acetyl‐4‐benzoyl‐1,5‐diphenylpyrazole reacts with DMF‐DMA to give the novel enaminone 2. The reaction of the latter with various hydrazonoyl halides afforded regioselectively the respective substituted (3‐pyrazolyl)(4‐pyrazolyl)ketones 4 in good over all yield. The preliminary screening for the antitumor activity of the synthesized compounds 2 and 4a, 4b, 4c, 4d, 4e, 4f, 4g against human breast cancer cell line (MCF‐7) revealed that both compounds 2 and 4b have high‐antitumor activity. SAR is discussed. J. Heterocyclic Chem., 46, 548 (2009).
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