One-pot synthesis of new series of pyranopyridine derivatives using 3-cyano-6-hydroxy-4-methyl-pyridin-2(1H)-one as a novel nucleophile

Immobilized Cu(II) Schiff base complex supported on Fe3O4 magnetic nanoparticles: A highly efficient and reusable new catalyst for the synthesis of pyranopyridine derivatives

“…Non-commercial 2-pyridone (3) was synthesized according to a reported procedure. [39,41] The characterization data for the catalyst and the titled products are available online in the Supporting Information section at the end of the article. ] molar ratio of 2:1 as described in the literature.…”

“…[29] The fused pyran ring skeleton is a well-known heterocyclic structure and important core unit in a number of natural products. [39] Also in a related study, we utilized guanidinium chloride-functionalized γ-Fe 2 O 3 /HAp magnetic nanoparticles as a novel heterogeneous nanocatalyst for the threecomponent synthesis of some new 4H-pyrano [2,3-b] pyridin-2-one derivatives. [31] Pyran heterocycles embedded with pyridine moiety as a fused component have occupied important position in bioorganic chemistry due to their important biological activities such as antimalarial, [32] anti-HIV, [33] anti-proliferative, [34] anti-inflammatory, anti-allergic and estrogenic properties.…”

“…Recently, we have reported the synthesis of 4H-pyrano[2,3-b]pyridin-7-ones using 3-cyano-6-hydroxy-4-methyl-pyridin-2(1H)-one as a novel nucleophile in the presence of Et 3 N catalyst. [39] Also in a related study, we utilized guanidinium chloride-functionalized γ-Fe 2 O 3 /HAp magnetic nanoparticles as a novel heterogeneous nanocatalyst for the threecomponent synthesis of some new 4H-pyrano [2,3-b] pyridin-2-one derivatives. [40] In this paper, we report facile immobilization of a Cu(II) Schiff base complex on synthesized Fe 3 O 4 MNPs as an efficient heterogeneous nano-organometallic catalyst for synthesis of pyrano [2,3-b]pyridin-2-one derivatives (4a-n) via the one-pot condensation reaction of aromatic aldehydes (1a-n), malononitrile (2) and 3cyano-6-hydroxy-4-methylpyridin-2(1H)-one (3) under solvent-free conditions (Scheme 1).…”

Fe3O4‐supported Schiff‐base copper (II) complex: A valuable heterogeneous nanocatalyst for one‐pot synthesis of new pyrano[2,3‐b]pyridine‐3‐carboxamide derivatives

“…Among the eco-friendly processes, multicomponent reactions (MCRs) have attracted much interests as high atom-economy and convergent reactions. [52][53][54][55][56][57][58] Recently, few methods have been developed for the synthesis of pyrano [2,3-c] pyridines utilizing Et 3 N in refluxing ethanol and [BMIm]BF 4 ionic liquid. [42][43][44][45] Therefore, these reactions provide the scientists an efficient, time saving and atom economical approach to a wide variety of organic and bioorganic molecules including heterocyclic compounds.…”

“…These well-known heterocyclic compounds have shown a broad range of biological properties such as antiallergic, antitumor, anti-inflammatory, antidyslipidemic, antimicrobial, antihyperglycemic, antiviral and estrogenic agents. [52][53][54][55][56][57][58] Recently, few methods have been developed for the synthesis of pyrano[2,3-c] pyridines utilizing Et 3 N in refluxing ethanol and [BMIm]BF 4 ionic liquid. [59] Also, Pyrano[3,2-c]pyridones have been synthesized by two stepwise procedures in refluxing methanol in the presence of piperidine.…”