One pot synthesis of new poly(vinyl alcohol) blended natural polymer based magnetic hydrogel beads: Controlled natural anticancer alkaloid delivery system

Abstract

Facile one-pot synthesis has been demonstrated for new biocompatible and dual responsive magnetic iron oxide nanoparticles cross-linked poly(vinyl alcohol) (PVA) blended natural polymer chitosan (CS) based hydrogel beads (mCS-PVA) as a controlled natural anticancer alkaloid Luotonin A (LuA) delivery system. The prepared magnetic hydrogel beads were characterized using powder X-ray diffraction measurement, Fourier transform-infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, and vibrating sample magnetometer. The magnetic hydrogel beads are exhibited significant water retention and follow the second order kinetic model in swelling study. The swelling ratio of the magnetic gel beads increased by the addition of PVA and showed a maximum swelling ratio of 40.83 ± 1.01 g/g and follows non-Fickian water transport mechanism. Stimuli responsive mCS and mCS-PVA hydrogel beads functionalized with LuA is demonstrated for controlled release at physiological pH and under magnetic field. The magnetic hydrogel beads show highest LuA releasing efficacy at acidic medium (pH = 5.0) with maximum efficiency of 73.33 ± 1.44%. This efficacy may also be tuned by altering the external magnetic field as well as the weight percentage (wt %) of polyethylene glycol. It is clearly that the newly produced magnetic hydrogel beads can be served as an effective intestinal LuA delivery system. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 543-551, 2018.

Magnetic iron oxide nanoparticles (MIONs) cross‐linked natural polymer‐based hybrid gel beads: Controlled nano anti‐TB drug delivery application

“…Releasing of nano RIF from the mCS‐PEG gel beads were found to be higher than same in the absence of the magnetic field. This indicated that the magnetic field as an external stimulus inducing the release of nano RIF from the magnetic gel beads . The mechanism involved as the applied magnetic field collapses the cross‐linking pattern of the CS‐PEG gel network via attracting the crosslinked MIONs toward the edges of sphere shaped gel beads (Scheme ).…”

“…This indicated that the magnetic field as an external stimulus inducing the release of nano RIF from the magnetic gel beads. 43 The mechanism involved as the applied magnetic field collapses the cross-linking pattern of the CS-PEG gel network via attracting the crosslinked MIONs toward the edges of sphere shaped gel beads (Scheme 4). As a result, the loaded nano drugs on polymer chains as well as on the surface of MIONs were released through diffusion.…”

Preparation, Characterization, and Biological Testing of Novel Magnetic Nanocomposite Hydrogels

“…However, any potential polysorbate 80 surfactant residue and the hydrogel’s pore structure are easy problems to solve . The selection of polysorbate 80 surfactant in the preparation process should be done to ensure sufficient pore formation and to allow for a standard structure …”

“…24 The selection of polysorbate 80 surfactant in the preparation process should be done to ensure sufficient pore formation and to allow for a standard structure. 25 Due to their good histocompatibility and low immunogenicity, hydrogels have inherent advantages in medical research and application. The introduction of magnetic particle materials makes the hydrogels responsive to magnetic fields, which is in line with current medical science and the increasing demand for medical materials to be intelligent and controllable.…”

<p>Synthesis, Characterization, Biomedical Application, Molecular Dynamic Simulation and Molecular Docking of Schiff Base Complex of Cu(II) Supported on Fe3O4/SiO2/APTS</p>

“…[4][5][6] Nanostructured materials functionalized with organic or inorganic coatings were developed as alternatives for the clinical studies of cancer therapy through attacking solid tumors. [6][7][8][9][10][11] The use of magnetic nanoparticles was introduced as a novel technical approach for cancer diagnosis and treatment with optimum anti-cancer effects. 12 Furthermore, L-lysine, L-arginine and 3-aminopropyltriethoxysilane (APTES) were employed to coat negatively charged nanoparticles; this increased the chances of nanoparticles binding to the anionic cell membrane.…”