One-Pot Synthesis of Mannich Bases Under Solvent-Free Conditions

[BCMIM][Cl] ionic liquid catalyzed diastereoselective synthesis of β‐amino ketones via facile, one‐pot, multicomponent Mannich reaction under solvent‐free condition

“…Other significant techniques for producing β-amino ketones include multicomponent Mannich reaction of ketones, aldehyde, and amines [21]. Usually, the general methods for the preparation of β-amino ketones involve cyclohexanone, substituted aromatic aldehydes, and substituted aromatic amines in one pot, multicomponent reactions include using 1-butyl-3-methylimidazolium ionic liquids (ILs) with different acidic anions as solvents [22], organobismuth complex [23], aqueous HBF 4 [24], H 3 PW 12 O 40 [25], Bronsted [26], Lewis acids [27], Lewis bases [28], o-benzenedisulfonimide [29], Silica supported perchloric acid (HClO 4 -SiO 2 ) [30], NaBAr 4 F [31], bisphosphorylimides [32], ZrOCl 2 Á8H 2 O [21], acetic acid [33], p-dodecyl benzenesulfonic acid [34], Bi(OTf) 3 [24], heteropoly acid [35,36], lipase [37], proline [38,39], NbCl 5 [40], polyelectrolyte Bronsted acid catalysts in the water medium [41], tetra nitrile silver complex [42], SO 4 2À /TiO 2 [43], camphor sulfonate based PILS [44], Bu 2 Sn(OMe) 2 [45], acid-ILs polymer in ACN solvents (Scheme 1) [46]. Unfortunately, the majority of these methods still have some drawbacks, including longer reaction times, harsher reaction conditions, the use of metal-supported catalysts, IL with the other metal cocatalysts, the use of toxic solvents, corrosive waste products and lengthy separation, repetitive work, chromatographic separation purification, and issues with recovering and reusing catalysts [47][48][49][50][51].…”

Recent progress in the chemistry of β-aminoketones

“…[33][34][35][36][37][38] b-Aminoketones were efficiently prepared under mild, green, and catalyzed conditions. [39][40][41] Specically, Mannich reactions were further applied in the synthesis of a variety of adaptable compounds incorporating a b-aminoketone motif in water following green approaches, comprising coumarins, 42 Betti bases, 43 spiro heterocycles, 44 oxindoles, 45 and uorinated aminoketones 46 (Fig. 2).…”

Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones

“…11 Inspired by these achievements, it is still highly desirable to construct β-aminoketone skeletons under milder, green, and environmental benign reaction conditions to meet the demands of drug developments. 12 Herein, we present a metal-free reductive hydroamination of ynones to deliver the corresponding β-aminoketones under very mild reaction conditions (Fig. 2C).…”