One‐pot synthesis of magnetic sulfonated covalent organic polymer for extraction of protoberberine alkaloids in herbs and human plasma

Abstract

A novel magnetic sulfonated covalent organic polymer was prepared for magnetic solid‐phase extraction of protoberberine alkaloids. The magnetic sulfonated covalent organic polymer was rapidly synthesized under mild conditions. The physicochemical properties of the prepared materials were characterized by Fourier‐transform infrared spectrometry, transmission electron microscopy, and X‐ray photoelectron spectroscopy. Several extraction parameters were systematically investigated, including desorption time, pH of sample solution, acetonitrile content, acetic acid content in the eluent, extraction time, and sample volume. By coupling magnetic solid‐phase extraction and high‐performance liquid chromatography, an efficient and sensitive method for the extraction and determination of protoberberine alkaloids in complex samples was developed. The proposed method showed great linearity (r > 0.9989), low limits of detection (0.2–0.3 ng/ml), and high precision (relative standard deviations ≤ 5.74%). The proposed method was further applied to the analysis of protoberberine alkaloids in Cortex phellodendri and human plasma samples. The recoveries were 91.50%–110.31% with relative standard deviations less than 6.63% in Cortex phellodendri and 96.12%–111.20% with relative standard deviations lower than 5.56% in plasma samples.

Preparation of COPs Mixed Matrix Membrane for Sensitive Determination of Six Sulfonamides in Human Urine

“…Therefore, COPs hold excellent potential for sample pretreatment. Ma et al [34] developed a novel covalent magnetic sulfonated organic polymer for solid-phase magnetic extraction of protoberberine alkaloids. Wei et al [35] synthesized an imine-based porous 3D COP, which proved an effective solid-phase sorbent for detecting amphenicols in water samples.…”