One‐pot synthesis of ICG&Cur@ZIF‐8 nanocomposites with pH‐controlled drug delivery and good photothermal performance

Abstract

Combination therapy has shown great potential for effective cancer treatment. In this work, anticancer drug curcumin (Cur) and photothermal agent indocyanine green (ICG) have been encapsulated into the pH-responsive ZIF-8 simultaneously to obtain ICG&Cur@ZIF-8 through one-pot synthesis method. The drug loading capacity was estimated as 9.6 and 12.3 wt% for Cur and ICG, respectively. As expected, ICG&Cur@ZIF-8 exhib-ited the pH-responsive ICG and Cur delivery, which was ascribed to the decomposition of ZIF-8 in acidic environment. Moreover, ICG&Cur@ZIF-8 also showed the high photothermal performance due to the efficient encapsulation of ICG. The codelivery of two therapeutic agents may bring more opportunities for biomedical application.

Engineering zeolitic imidazolate framework-8 nanoparticles for smart drug delivery systems

“…The one-pot method is one of the easiest, most costeffective and efficient methods for loading drugs into MOFs. So far, many drugs have been reported to be successfully encapsulated in ZIF-8 NPs by this method, such as DOX [41], hinokiflavone (HF) [42], camptothecin [43], curcumin [44], 3-methyladenine (3-MA) [40], etc Su et al [45] successfully synthesized ICG&Cur@ZIF-8 NPs by encapsulating both anticancer drug curcumin (Cur) and photothermal agent indocyanine green (ICG) in ZIF-8 NPs by one-pot method, and thus the synthesized ICG&Cur@ZIF-8 NPs have pH-responsive drug delivery and good photothermal properties. In addition, some enzymes have also been successfully packaged into ZIF-8 NPs.…”

Enhanced n‐butanol permselective vapor permeation by incorporating ZIF‐8 into a polydimethylsiloxane composite membrane: Effect of filler loading contents

“…Metal-organic frameworks (MOFs) are a class of compounds constructed from multitopic organic ligands and metal ions/ clusters, and have been widely explored due to their special features, including extremely high porosities, cage-like structure, and tunable optical properties. [15][16][17][18][19] In specific, as a subclass of MOFs, zeolitic imidazolate frameworks (ZIFs) have been focused in the fields of photocatalytic degradation, [20] drug delivery, [21] photodynamic therapy, [22] electrochemical oxdidation, [23] adsorption, [24] and luminescent sensing. [25] Compared to other inorganic fillers, ZIF-8 nanoparticles offers better compatibility with the organic PDMS matrix for MMMs.…”