One-pot synthesis of hierarchical-pore metal–organic frameworks for drug delivery and fluorescent imaging

Gao, Xuechuan; Wang, Yuewu; Ji, Guanfeng; Cui, Ruixue; Liu, Zhiliang

doi:10.1039/c7ce02053h

Cited by 68 publications

(48 citation statements)

References 32 publications

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“…The unsaturated metal sites on the surface of the NMOFs can continue to coordinate with other biofunctional molecules to improve their biological cognitive function for enhancing the targeted imaging of tumors . Some groups have also tried to combine imaging agents such as rhodamine b with NMOFs by a one‐pot synthesis to acquire an imaging complex . In addition, the controllability of metal centers and organic ligands endows them with the ability to be independent imaging reagents.…”

Section: Imagingmentioning

confidence: 99%

Nanoscale Metal‐Organic Frameworks: Synthesis, Biocompatibility, Imaging Applications, and Thermal and Dynamic Therapy of Tumors

Tan

Meng

2020

Adv Funct Materials

121

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Nanoscale metal‐organic frameworks (NMOFs) have attracted increasing attention for biomedical applications due to their large specific surface area, good biocompatibility, adjustable structures, and diverse functions. By choosing appropriate metal ions and ligands, NMOFs can be synthesized and regulated to assist the diagnosis and treatment of cancer, acting as imaging agents, drug carriers, and cancer therapeutic agents. This review summarizes the recent advances of NMOFs in synthesis, biocompatibility, imaging, and applications in cancer therapies. Among these, the term “biocompatibility” is used to outline their various biological characteristics, and it is mainly discussed from the aspects of size and surface properties of NMOFs. The imaging section mainly emphasizes the application advantages of NMOFs as imaging agents in magnetic resonance, computed tomography, and fluorescence imaging. The applications of NMOFs in four cancer therapies, including phototherapy, radiotherapy, microwave therapy, and ultrasonic therapy, are addressed, especially for thermal and dynamic therapy. Finally, the prospects and challenges of NMOFs in imaging and cancer therapies are also discussed.

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Section: Imagingmentioning

confidence: 99%

Nanoscale Metal‐Organic Frameworks: Synthesis, Biocompatibility, Imaging Applications, and Thermal and Dynamic Therapy of Tumors

Tan

Meng

2020

Adv Funct Materials

121

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“…Conversely, we discovered that the RhB@ZIF-71 exhibits good luminescence ( Figure S14 and Figure 6) in non-polar solvents, and even show sensing property previously not achievable by pure RhB alone. To date, most of the RhB@MOF studies [17][18][19][20][21][22][23][24] have focused on the field of solvatochromism, and many of these systems possess the similar sensing behaviour.…”

Section: Solvatochromic Sensing Responsementioning

confidence: 99%

“…In this study, we demonstrate a facile method to synthesize a multi-stimuli responsive Guest@MOF luminescent material, by embedding the well-known luminescent dye rhodamine B (RhB) into zeolitic imidazolate framework-71 (ZIF-71). Although a number of RhB@MOF systems have been reported, [17][18][19][20][21][22][23][24] there are certain limitations, such as the use of complex synthesis steps, no control of RhB aggregates, inadequate explanation of the underlying mechanisms, and monotonous functionality (basically only solvatochromism). In contrast, our RhB@ZIF-71 not only shows solvatochromic response with its sensitivity far surpassing all reported examples, [17][18][19][20][21][22][23][24] but also exhibits exceptional mechanochromic and thermochromic sensing properties that are unknown to date.…”

Section: Introductionmentioning

confidence: 99%

Multichromic Metal-Organic Framework for Multimode Photonic Sensing

Zhang¹,

Chaudhari²,

Gutiérrez³

et al. 2020

Preprint

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Luminescent metal-organic frameworks (MOFs) offer a multifunctional platform for engineering non-invasive sensors and tuneable optoelectronics. However, multichromic materials that are photophysically resilient and show high sensitivity towards different physical and chemical stimuli are scarce. We report a facile host-guest nanoconfinement strategy to construct a hybrid material with multichromic sensing capabilities. We design and fabricate a new Guest@MOF material: comprising a zeolitic MOF (ZIF-71), acting as a nanoporous host for encapsulating rhodamine B (RhB) guest molecules, resulting in the RhB@ZIF-71 system with mechanochromic, thermochromic, and solvatochromic sensing response. The multichromic properties stem from the nanoconfinement effect that ZIF-71 imposes on RhB monomers, yielding the H-type or J-type aggregates with tuneable photophysical and photochemical properties. For mechanochromism, the external pressure causes an emission red shift in a linear fashion, switching the RhB guests from H-type to J-type aggregates via a shear mechanism. For thermochromism, we demonstrate a linear scaling as a function of temperature due to the spatial restriction experienced by J-type aggregates incarcerated in ZIF-71 pores.Harnessing the solvatochromism of RhB@ZIF-71, we identified three diverse groups of volatile organic compounds. The multimodal response could pave the way to smart applications like photonic pressure sensors, non-invasive thermometers, and ultrasensitive chemosensors.

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“…Coordination polymers (CPs), an emerging type of inorganic–organic hybrid material, are fabricated through self‐assembly of inorganic metal ions/clusters and organic linkers . CPs have attracted enormous attention from chemists owing to their fascinating topological structures, diverse functionalities, and versatile application in the areas of gas storage and separation, heterogeneous catalysis, energy storage, drug delivery, magnetism, and luminescence . The properly design and synthesis of multifunctional CPs have attracted increasing research interest.…”

Section: Introductionmentioning

confidence: 99%

Syntheses, structures, and properties of four coordination polymers based on 2,7‐di(pyridin‐4‐yl)‐9H‐fluoren‐9‐one

Liu

Wang

Chen

et al. 2020

Applied Organom Chemis

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Four coordination polymers (CPs), [Cd(2,7‐dpfo)2(NO3)2(CH3OH)]n (1), [Zn(2,7‐dpfo)(NO3)(CH3COO)]n (2), [Co(2,7‐dpfo)2(H2L)]n (3), and [Ni(2,7‐dpfo)2(H2L)]n (4) (where 2,7‐dpfo is 2,7‐di(pyridin‐4‐yl)‐9H‐fluoren‐9‐one and H4L is 1,1′:4′,1′′‐terphenyl‐4,2′,5′,4′′‐tetracarboxylic acid), were synthesized and structurally characterized. Compounds 1–4 were determined by elemental analyses, single crystal X‐ray diffraction analyses, powder X‐ray diffraction, infrared spectroscopy, and thermogravimetric analyses. Compound 1 displays a one‐dimensional (1D) zigzag chain structure, while compound 2 possesses a 1D ladder chain structure. Compounds 3 and 4 are isostructural and consist of 1D chains. The solid‐state luminescent properties of 1 and 2 and the magnetic properties of 3 and 4 were also investigated.

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One-pot synthesis of hierarchical-pore metal–organic frameworks for drug delivery and fluorescent imaging

Abstract: A one-pot process has been developed for the synthesis of hierarchical-pore metal–organic frameworks, aimed at loading large and small drug molecules simultaneously.

Cited by 68 publications

References 32 publications

Nanoscale Metal‐Organic Frameworks: Synthesis, Biocompatibility, Imaging Applications, and Thermal and Dynamic Therapy of Tumors

Nanoscale Metal‐Organic Frameworks: Synthesis, Biocompatibility, Imaging Applications, and Thermal and Dynamic Therapy of Tumors

Multichromic Metal-Organic Framework for Multimode Photonic Sensing

Syntheses, structures, and properties of four coordination polymers based on 2,7‐di(pyridin‐4‐yl)‐9H‐fluoren‐9‐one

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