One-pot synthesis of glutathione-responsive amphiphilic drug self-delivery micelles of doxorubicin–disulfide–methoxy polyethylene glycol for tumor therapy

Abstract

We present a novel glutathione-responsive amphiphilic drug self-delivery (DSD) micelle with one-pot synthesis to synergistically address the problems of controlled drug release, degradability, drug tracing and in vivo accumulated toxicity.

pH/Reduction Dual‐Triggered Degradable Poly(doxorubicin) Prodrug Nanoparticles for Leakage‐Free Tumor‐Specific Self‐Delivery

“…Most recently, Duan et al. reported the first example of DOX‐based polymer prodrug with DOX units in the prodrug polymer backbone . The DOX–disulfide–methoxy polyethylene glycol was designed as glutathione‐responsive drug self‐delivery micelles for tumor therapy, with DOX content of 25.5%.…”

Nitrogen‐Rich Porous Organic Polyamines for Stabilization of Highly Dispersed Metal Nanoparticles and Catalytic Application

“…Compared to inorganic porous materials or porous carbon materials, porous organic polymers (POPs) possess favorable advantage for stabilizing metal NPs. Numerous POPs including hyper‐cross‐linked polymers (HCPs), conjugated microporous polymers (CMPs), covalent organic frameworks (COFs), hyperbranched polymers (HBPs), and dendrimers have been employed to prepare metal NPs supported catalysts (metal NPs@POPs). The metal NPs loaded on POPs supports show high atom utilization, excellent catalytic activity, and stable recyclability.…”

Self‐Assembly of Drug–Drug Conjugates as Drug Self‐Delivery System for Tumor‐Specific pH‐Triggered Release

“…To overcome these problems, drug self‐delivery systems (DSDSs) have been developed most recently, exhibiting nanoscale characteristic to endow intracellular delivery by themselves without any nanocarriers, as drug–drug conjugates, polymer prodrugs, or molecular hydrogels . Such nano‐DSDSs could release therapeutics or their derivatives by cleaving the conjugating linkages, responding to the acidic media or high reductant level in tumor microenvironment.…”

“…PEGylation has been recognized to improve the pharmacokinetic and pharmacodynamic outcomes of therapeutics . Among the nano‐DSDSs, the prolonged blood circulation time was desired for those with higher drug content but without PEGylated, while the PEGylation led a lower drug content in the others . Furthermore, lower tumor‐inhibition efficacy was achieved than the free chemotherapeutics in some cases, because the drug was released as its derivative …”