One‐Pot Synthesis of Fused [1,6]Naphthyridine Derivatives via Three‐Component Reaction

Abstract

A simple, convenient, and eco‐friendly synthetic protocol has been developed via a one‐pot three‐component reaction between 2‐chloroquinoline‐4‐amines, different substituted aromatic aldehydes, and malononitrile using ethanol as reaction medium. Employing this protocol, a series of 5‐chloro‐4‐phenyl benzo[f][1,6] naphthyridine‐2‐amino‐3‐carbonitrile derivatives were synthesized in an environmentally friendly approach under operational simplicity, short time reactions, easy work‐up procedure, and comparatively high yields. This chemistry provides a convenient and promising synthetic strategy for the construction of the napthyridine skeleton. All synthesized compounds were identified on the basis of their spectral data.