One-pot synthesis of (E)-3-benzylideneflavanones from 2-hydroxyacetophenones and aromatic aldehydes

Yang, Lishou; Wang, Enhua; Fan, Yanhua; Yang, Juan; Luo, Zhongsheng; Wang, Yu; Peng, Mei; Deng, Tingfei; Xiao-sheng, Yang

doi:10.1016/j.tetlet.2019.151180

Cited by 7 publications

(1 citation statement)

References 15 publications

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“…Our group has developed an efficient and practical PPA/H 2 SO 4 promoted one-pot synthesis of ( E )-3-benzylideneflavanones ( Scheme 1b ), 16 which inspired us to explore the one-pot synthesis of flavanones. Although the synthesis of flavanone via the cyclization of chalcone using PPA have been reported, 7 d we wish to describe another efficient one-pot procedure promoted by PPA for the synthesis of flavanone derivatives directly from readily available 2-hydroxyacetophenones and benzaldehydes ( Scheme 1c ).…”

Section: Introductionmentioning

confidence: 99%

Polyphosphoric acid-promoted one-pot synthesis and neuroprotective effects of flavanones against NMDA-induced injury in PC12 cells

Wang¹,

Yang

Yang³

et al. 2022

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Polyphosphoric acid-promoted one-pot synthesis and neuroprotective effects of flavanones against NMDA-induced injury in PC12 cells

Wang¹,

Yang

Yang³

et al. 2022

RSC Adv.

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3‐Arylidene‐4‐Chromanones and 3‐Arylidene‐4‐Thiochromanones: Versatile Synthons towards the Synthesis of Complex Heterocycles

2022

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Heterocyclic compounds are well-known for their use in the synthesis of drugs and drug intermediates. This review provides a systematic survey on the chemical synthesis of complex heterocyclic compounds containing multistereocentres using 3-arylidene-4-chromanones in the last two decades. Regioselective and stereoselective synthesis of complex heterocycles involving 3-arylidene-chromanones and 3-arylidene-thiochormanones are dealt under various reaction headings such as epoxidation, Michael addition, 1,3dipolar cycloaddition, [3 + 2] and [4 + 2] cycloaddition, Diels-Alder reaction, sulfa-Michael/aldol cascade reactions, asym-metric synthesis employing bifunctional catalysts, chiral phase-transfer catalysts, chiral squaramide catalysts, etc. These synthetic highlights demonstrate the utility of 3arylidene-4-chromanones and 3-arylidene-thiochormanones as versatile synthons for rapid assemblage of complex condensed heterocyles and spiro-fused heterocycles towards the development of pharmaceutically active compounds. A brief highlight on the synthetic methods of 3-arylidene-4chromanone derivatives is also dealt. This review creates a platform for further improvement on the skeletal design of potential drug candidates.

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Fluorinated 2-arylchroman-4-ones and their derivatives: synthesis, structure and antiviral activity

Troshkova,

Politanskaya,

Bagryanskaya

et al. 2023

Mol Divers

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One-pot synthesis of (E)-3-benzylideneflavanones from 2-hydroxyacetophenones and aromatic aldehydes

Cited by 7 publications

References 15 publications

Polyphosphoric acid-promoted one-pot synthesis and neuroprotective effects of flavanones against NMDA-induced injury in PC12 cells

Polyphosphoric acid-promoted one-pot synthesis and neuroprotective effects of flavanones against NMDA-induced injury in PC12 cells

3‐Arylidene‐4‐Chromanones and 3‐Arylidene‐4‐Thiochromanones: Versatile Synthons towards the Synthesis of Complex Heterocycles

Fluorinated 2-arylchroman-4-ones and their derivatives: synthesis, structure and antiviral activity

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