One-pot synthesis of dopamine-conjugated hyaluronic acid/polydopamine nanocomplexes to control protein drug release

Lim, Dae Gon; Prim, Racelly Ena; Kang, Eung Shick; Jeong, Seong Hoon

doi:10.1016/j.ijpharm.2018.03.007

Cited by 27 publications

(18 citation statements)

References 51 publications

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“…[43] Overall, complex formation still appears to be treated asabasic requirement even as new reports on non-covalentp olymer-protein complexes emerge. [44,45] For example, in another study,t ransmission electron microscopy (TEM) and dynamic light scattering (DLS) experiments confirmed the ability of Pep-1 to form complexes and determined complex sizes that were then correlated with delivery efficiency (Figure 8). [46] Emphasizing size after verificationo fc omplex formation seems to represent another standard approachi nt he field for studying non-covalent polymer-protein complexes for use in intracellulardelivery.…”

Section: Other Non-covalent Protein-basedcomplexes For Deliverymentioning

confidence: 92%

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Associative and Dissociative Processes in Non‐Covalent Polymer‐Mediated Intracellular Protein Delivery

Posey

Tew

2018

Chemistry An Asian Journal

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Functional protein delivery has created new opportunities for studying intracellular processes and discovering new therapeutics. To that end, researchers have pursued intracellular protein delivery by using an increasing number of methods. This focus review will highlight polymeric carriers that non-covalently bind and deliver protein cargo in vitro. The correlation between polymer-protein binding and delivery as well as the correlation between complex-membrane binding and delivery is reviewed. Finally, binding and its relation to the intracellular function of the protein post-delivery is considered. The purpose of this review is to evaluate the role that binding interactions play in the non-covalent protein-delivery landscape. Presently, the literature does not adequately resolve how binding throughout the process ultimately affects delivery. The field does contain preliminary insights that are expected to impact future delivery applications when developed further.

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Section: Other Non-covalent Protein-basedcomplexes For Deliverymentioning

confidence: 92%

“…Further discussion about correlating size with delivery,t hough relevant to the topics reviewed here, is beyondt he scope of this review,a nd more information can be found in Refs. [45][46][47][48][49].…”

Section: Other Non-covalent Protein-basedcomplexes For Deliverymentioning

confidence: 99%

Associative and Dissociative Processes in Non‐Covalent Polymer‐Mediated Intracellular Protein Delivery

Posey

Tew

2018

Chemistry An Asian Journal

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“…Since it is hydrophilic, several reactions are performed in aqueous media [145][146][147]: however, they are pH-dependent and, therefore, require acidic or alkaline conditions, which, if too strong, can determine HA degradation [75,145]. Other synthetic methods, involving the use of reagents sensitive to hydrolysis, are performed in anhydrous organic solvents such as dimethylsulfoxide (DMSO) [146] or dimethylformamide (DMF) [148].…”

Section: Preprints (Wwwpreprintsorg) | Not Peer-reviewed |mentioning

confidence: 99%

“…Since HA derivatives of high quality and purity are necessary to develop injectable products, implantable scaffolds, drug delivery systems, and 3D hydrogel matrices encapsulating living cells, techniques for efficient, low-cost and safe modification of HA are continuously being explored [46,147,149]. Hence, in the last years, several efforts have been done to introduce one-pot reactions which preferably proceed in aqueous ambient, under mild and, possibly, environmental-friendly conditions, and without the use of toxic catalysts and reagents [147,149].…”

Section: Preprints (Wwwpreprintsorg) | Not Peer-reviewed |mentioning

confidence: 99%

“…Hence, in the last years, several efforts have been done to introduce one-pot reactions which preferably proceed in aqueous ambient, under mild and, possibly, environmental-friendly conditions, and without the use of toxic catalysts and reagents [147,149]. Additionally, alternative approaches to efficiently modify HA have been introduced: solvent-free methods -i.e.…”

Section: Preprints (Wwwpreprintsorg) | Not Peer-reviewed |mentioning

confidence: 99%

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Hyaluronic Acid in the 3<sup>rd</sup> Millennium

Fallacara¹,

Baldini²,

Manfredini³

et al. 2018

Preprint

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Since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid is almost ubiquitary in humans and in other vertebrates. HA is involved in many key processes -including cell signaling, wound reparation, tissue regeneration, morphogenesis, matrix organization and pathobiology-, and has unique physico-chemical properties -such as biocompatibility, biodegradability, mucoadhesivity, hygroscopicity and viscoelasticity. For these reasons, exogenous HA has been investigated as drug delivery system and treatment in cancer, ophthalmology, arthrology, pneumology, rhinology, urology, aesthetic medicine and cosmetic. To improve and customize its properties and applications, HA can be subjected to chemical modifications: conjugation and crosslinking. The present review gives an overview regarding HA, describing its history, physico-chemical, structural and hydrodynamic properties, and biology -occurrence, biosynthesis (by hyaluronan synthases), degradation (by hyaluronidases and oxidative stress), roles, mechanisms of action and receptors. Furthermore, both conventional and recently emerging methods developed for the industrial production of HA and its chemical derivatization are presented. Finally, the medical, pharmaceutical and cosmetic applications of HA and its derivatives are reviewed, reporting examples of HA-based products which currently are on the market or are undergoing further investigations.

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3D‐Printed Tissue‐Specific Nanospike‐Based Adhesive Materials for Time‐Regulated Synergistic Tumor Therapy and Tissue Regeneration In Vivo

Lee,

Han,

et al. 2024

Adv Funct Materials

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The growing concerns regarding cancer recurrence, unpredictable bone deficiencies, and postoperative bacterial infections subsequent to the surgical removal of bone tumors have highlighted the need for multifaceted bone scaffolds that afford tumor therapy, bacterial therapy, and effective vascularized bone reconstruction. However, challenging trilemma has emerged in the realm of bone scaffolds regarding the balance between achieving appropriate mechanical strength, ensuring biocompatibility, and optimizing a degradation rate that aligns with bone‐regenerative rate. Considering these challenges, innovative theragenerative platform is developed by utilizing 3D printing‐based nanospikes for the first time. This platform comprises tissue‐specific nanospiked hydroxyapatite decorated with magnesium (nMg) and adhesive DNA (aDNA). The incorporation of nMg within polylactic acid (PLA) matrix confers photothermal capabilities and helps to modulate mechanical and degradation properties and improve the biocompatibility of theragenerative platform. Simultaneously, the immobilized aDNA contributed to the enhancement of vascularized bone healing. These 3D‐printed tissue‐adhesive theragenerative platforms exhibit superior mechanical properties and offer controlled degradability. Moreover, they enable the eradication of bacteria and osteosarcoma through hyperthermia and promote angiogenesis and osteogenesis, both in vitro and in vivo. This groundbreaking approach is poised to pave the way for the fabrication and design of novel implantable biomaterials that integrate therapeutic and regenerative functions.

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One-pot synthesis of dopamine-conjugated hyaluronic acid/polydopamine nanocomplexes to control protein drug release

Cited by 27 publications

References 51 publications

Associative and Dissociative Processes in Non‐Covalent Polymer‐Mediated Intracellular Protein Delivery

Associative and Dissociative Processes in Non‐Covalent Polymer‐Mediated Intracellular Protein Delivery

Hyaluronic Acid in the 3<sup>rd</sup> Millennium

3D‐Printed Tissue‐Specific Nanospike‐Based Adhesive Materials for Time‐Regulated Synergistic Tumor Therapy and Tissue Regeneration In Vivo

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