One Pot Synthesis of AuPdPt Trimetallic Nanohybrid Decorated Reduced Graphene Oxide Nanosheets for Ultrasensing of Anti-Convulsant Drug Retigabine (Ezogabine)

Abstract

Herein, a simple reduction method for decoration of reduced graphene oxide (RGO) nanosheets with AuPdPt trimetal nanoparticles was developed. The as-synthesized nanocomposite was characterized detailedly using several techniques such as SEM, TEM, FTIR, CV and EDS. The results showed that the trimetal nanoparticles are well dispersed on RGO nanosheets, preventing the serious aggregation and maintaining good electro-catalytic activity. Benefiting from synergistic effect of AuPdPt nanoparticles and RGO, the modified electrode exhibited higher and remarkable oxidation toward retigabine (REG), anti-convulsant drug, with lowered oxidation overpotential. Under the optimum conditions for electrochemical oxidation of REG, the AuPdPt NPs@RGO/GCE displayed a wide linear range of 0.1−40.0 × 10 −7 M with LOD of 0.039 × 10 −7 M if compared to LODs of bare GCE, GO/GCE and RGO/GCE with values of 1.94 × 10 −7 M, 0.32 × 10 −7 M and 0.11 × 10 −7 M, respectively. The main merits of the proposed sensor are the good stability, selectivity and reproducibility which have been successfully applied for the analysis of REG in human plasma and urine samples with good percentage recoveries. The obtained results prove that the proposed sensor could be a promising and convenient material for the construction of reliable and high performance electrochemical sensors.

Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine

“…The diffraction peak at 11.6° corresponds to (0 1 1) plane of the graphene layer spacing d = 0.776 nm [48] . The diffraction peak in ZnS NPs@rGO at 24.6° corresponds to (0 0 2) plane of rGO [49] , [50] , [51] . The diffraction peaks at 28.6°, 33.8°, 48.2°, 56.8°, 59.8°, 69.3° and 76.4° correspond to the (1 1 1), (2 0 0), (2 2 0), (3 1 1), (2 2 2), (4 0 0) and (3 3 1) crystalline planes of ZnS, which agree well with JCPDS number 05-0566 [52] , [53] .…”

Electrochemical Investigation of Caffeine by Cerium Oxide Nanoparticle Modified Carbon Paste Electrode

“…[47][48][49][50][51][52][53] For the elimination of toxic auto-exhaust gases from vehicles it acts as three-way catalysts (TWC) supporter. [54][55][56] Cerium dioxide nanoparticles (CeO 2 NPs) have caught attention of researchers to build amperometry biosensors as they have high oxygen storage capacity, biocompatibility, high isoelectric point (IEP) (∼9.0) and chemical stability. For biomedical purposes soluble cerium salts have been used due to their bactericidal activity, [50][51][52] from cerium nitrate a dermal burn cream is formulated, is advertised as medicine obtainable allover European countries.…”