One-pot synthesis of AuPd@FexOy nanoagent with the activable Fe species for enhanced Chemodynamic-photothermal synergetic therapy

Strategies for enhancing cancer chemodynamic therapy performance

“…AFeNPs@CAI CDT MDA-MB-231 [35] FePt@FeOx@TAM-PEG CDT 4T1 [43] UCNP@PVP@MIL88B CDT U87MG [44] H 2 O 2 generation PTCG (EGCG, Pt-OH, PEG-b-PPOH) CDT/Chemotherapy HepG2 [17] Copper hexacyanoferrate CDT 4T1 [40] Den-DOX-Fe 3+ -TA CDT/Chemotherapy U14 [45] PGC-DOX (PEG-GOx, CaCuP, DOX) CDT/Chemotherapy 4T1 [46] ACC@DOX•Fe 2+ -CaSi-PAMAM-FA/mPEG CDT/Chemotherapy A375, 4T1 [47] (MSNs@CaO 2 -ICG)@LA CDT/PDT MCF-7 [48] PZIF67-AT CDT 4T1 [49] Copper peroxide nanodots CDT U87MG [50] GSH depletion FA-Pyrite CDT CT26 [34] MMDM (microphage, MCN, DOX, MnO 2 ) CDT/Chemotherapy 4T1 [51] A@P/uLDHs (artemisinin, PEG, MgFe-LDH) CDT HeLa [52] CCMZ (Cu, CuMoO x , ZP) CDT 4T1 [53] JNP Ve (Au-MnO JNPs, IR1061) CDT/Radiotherapy MCF-7 [54] DMON@Fe 0 /AT CDT 4T1 [55] CMBP (CuO/MnO x @BSA, Pt(IV) prodrug) CDT/Chemotherapy 4T1 [56] Zn x Mn 1−x S/PDA CDT/PTT 4T1 [57] PtCu 3 nanocage CDT/SDT 4T1 [58] External stimuli Light DGU:Fe/Dox CDT/Chemotherapy 4T1 [59] LET-6 (tPy-Cy-Fe, DSPE-PEG) CDT/PTT U87MG [60] GNR@SiO 2 @MnO 2 CDT/PTT U87MG [61] SnFe 2 O 4 nanozyme CDT/PTT/PDT 4T1 [62] MoSe 2 /CoSe 2 @PEG CDT/PTT H-22 [63] HULK (liposome, laccase, MOHQ, FeCe6) CDT 4T1 [64] Cu-OCNP/Lap CDT/PTT HeLa [65] AuPd@Fe x O y CDT/PTT A549 [66] Fe-doped MoO x nanowires CDT/PTT HeLa [67] Hollow magnetite nanoclusters CDT/PTT HeLa [68] ICG@Mn/Cu/Zn-MOF@MnO 2 CDT/PTT/PDT U87 [69] Wesselsite (SrCuSi 4 O 10 ) nanosheets CDT/PTT/Starvation therapy 4T1 [70] MoP 2 nanorods CDT/PTT CAL27 [71] X-ray Cu 2 (OH)PO 4 @PAAS CDT/Radiotherapy HeLa [72] CoFe 2 O 4 nanoparticles CDT/Radiotherapy MCF-7…”

Heterometallic nanomaterials: activity modulation, sensing, imaging and therapy

“…7,42 Alternatively, single particles tend to agglomerate together due to large surface energy, and consequently reduce the effective surface area and weaken the catalytic properties. [78][79][80][81][82] To address this issue, many materials such as carbon materials, 78,79,[83][84][85][86][87][88][89][90][91][92][93] metal oxides, [80][81][82][94][95][96][97][98][99][100][101][102][103][104][105][106][107] and suldes, [108][109][110][111] as well as metal organic frameworks (MOFs, consisting of organic ligands and metal ions) [112][113][114] have been explored as supports or wrapping materials recently. Among them, there are many carbon-and metal-oxide based hybrid nanomaterials, showing broad applications in sensing and analysis (Table 1).…”

“…19,28,63,77 Among them, a series of HMNM-based studies have turned from single-therapy to subtly integrate the above techniques, as the advantages of synergistic therapy strategies are certied. 71,77,100,188,218 Notably, two types of lasers are usually used to visibly optimize PTT and PDT effects in combined PTT/PDT, as well as suitable HMNMs with high PCE. 71,77 3.3.1 Radiotherapy.…”

“…232,233 Impressively, photothermal agents can greatly accelerate Fenton-like reactions by elevating the local temperature or reducing the local pH value of the tumor, ultimately converting optical energy into hyperthermia, as widely adopted in recent literature. 29,100,211,224,234 For example, Cu 2 Se hollow nanocubes (HNCs) were prepared with high PCE and improved Fenton-like properties. 44 Aer surface modication with PEG, the hybrid PEG-Cu 2 Se HNCs displayed photothermal-enhanced CDT, achieving signicantly enhanced efficacy in 4T1 tumor bearing mice (Fig.…”

“…Among them, there are many carbon- and metal-oxide based hybrid nanomaterials, showing broad applications in sensing and analysis (Table 1). 78–107 For example, a seed-mediated approach was developed for aqueous synthesis of heterodimeric structures such as AgPt alloy –Fe 3 O 4 and Au core @Pd shell –Fe 3 O 4 , 115 and they were adopted as excellent contrast agents in imaging modalities such as optical coherence tomography (OCT) and PA with excellent performances.…”