One-pot synthesis of albumin-gadolinium stabilized polypyrrole nanotheranostic agent for magnetic resonance imaging guided photothermal therapy

Yang, Zhe; He, Wenshan; Zheng, Hong-Yi; Wei, Jiaolong; Liu, Pei; Zhu, Wei; Lin, Leping; Zhang, L.; Yi, Changfeng; Xu, Zushun; Ren, Jinghua

doi:10.1016/j.biomaterials.2018.01.026

Cited by 64 publications

(34 citation statements)

References 50 publications

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“…PPy could be integrated with biomaterials and inorganic nanostructures for enhanced PTT. Recently, Ren et al . prepared PPy‐based nanotheranostic agents (PPy@BSA‐Gd) using bovine serum albumin (BSA) as stabilizer and biomineralized synchronously with Gd 3+ for T 1 ‐weighted magnetic resonance imaging (MRI)–guided PTT.…”

Section: Cps For Pttmentioning

confidence: 99%

Conjugated Polymer Materials for Photothermal Therapy

Sun

Liu

et al. 2018

Advanced Therapeutics

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Although many approaches including operative treatment, chemotherapy, and radiotherapy have been developed to struggle against cancer, they are still insufficient in clinical application owing to the non-ideal therapeutic efficiency and serious side effects. Photothermal therapy (PTT) is emerging as a novel alternative to the conventional therapies because of minimal invasiveness and high specificity. Conjugated polymers (CPs) with the merits of unique optical properties and biological activities have been extensively investigated as functional photothermal conversion materials. The critical design strategies of CPs with high photothermal conversion efficiency and excellent PTT effect are reviewed in this progress report. The major challenges and future development of CPs for PTT are also discussed.

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Section: Cps For Pttmentioning

confidence: 99%

Conjugated Polymer Materials for Photothermal Therapy

Sun

Liu

et al. 2018

Advanced Therapeutics

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“…However, inorganic photothermal nanomaterials have several disadvantages like poor colloidal stability, long residence time in the body and chronic toxicity. Conversely, organic photothermal conversion nanoagents like conjugated polymers, have been found to be promising in biological applications due to their good biocompatibility and biodegradability …”

Section: Introductionmentioning

confidence: 99%

Photothermal Composite Nanomaterials for Multimodal Tumor Therapy under MRI Guidance

et al. 2019

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Multifunctional nanomaterials for cancer therapy has attracted researchers’ attention for decades. In this study, a unique oxidative method using KMnO4 or K2MnO4 as oxidizing agents to oxidize dopamine (DA) to polydopamine (PDA) was reported. The oxidizing agent was reduced to MnOx to form MnOx/PDA composite NPs. Afterwards, the MnOx/PDA composite NPs were surface‐modified with bovine serum albumin (BSA) to form a multifunctional theranostic agent, named MnOx/PDA@BSA NPs, with improved colloidal stability and biocompatibility. Such a material would become a photothermal nanoagent, since the PDA renders the composite NPs an admirable photothermal transforming ability with the photothermal conversion efficiency of 27.06%. Meanwhile, as a commonly used T1 contrast agent, manganese (Mn2+) endowed the MnOx/PDA@BSA NPs with MRI ability, rendering the as‐synthesized MnOx/PDA composite NPs a capability of imaging guided multi‐modal tumor therapy. Moreover, the formed MnOx/PDA@BSA NPs were used for drug loading, which was found to own the tunable drug loading and controlled drug releasing capacity. The as‐prepared composite NPs were successfully used for the combined tumor chemotherapy and photothermal therapy in vitro and in vivo. This research provides insights into the development of conjugated polymer‐based nanomaterial for various biomedical applications, especially in imaging guided cancer therapy.

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“…Recently, PPy@Fe 3 O 4 nanoparticles were prepared via a FeCl 3 ‐mediated two‐step method for MR imaging‐guided PTT of tumors . Besides, PPy@BSA‐Gd nanoparticles have been fabricated via an oxidation and biomineralization‐based two‐step approach for MR imaging and PTT of tumors rather than via the rational choice of oxidizers . It is still challenging to synthesize imageable PPy nanoparticles, especially capable of CT imaging, via a one‐step strategy under mild conditions.…”

Section: Introductionmentioning

confidence: 99%

“…In the past decades, lots of inorganic (e.g., gold nanostructures, palladium nanosheets, and metal sulfide nanoparticles) and organic materials (e.g., carbon‐based nanomaterials, NIR dye, polydopamine, polyaniline, and polypyrrole (PPy)) have been explored for effective PTT application . Among them, PPy nanoparticles as the most promising conjugated polymer with strong NIR absorbance, high photothermal conversion efficiency, and excellent photostability have been regarded as an excellent photothermal agent for in vivo PTT with high therapeutic efficacy . To realize more effective, safe, and personalized PTT, imaging tools are needed to accurately identify the location and size of tumors, real‐time monitor the distribution of photothermal agents, and evaluate the therapeutic efficacy .…”

Section: Introductionmentioning

confidence: 99%

One‐Step Synthesis of Iodinated Polypyrrole Nanoparticles for CT Imaging Guided Photothermal Therapy of Tumors

Zou

Huang

Zhang

2018

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Theranostic materials are of great significance to a personalized precise medicine. However, conventional theranostic agents are mainly fabricated by combining presynthesized independent imaging probes and therapeutic agents, suffering from multiple synthesis procedures, poor morphological control, and time/reagent‐consuming process. Herein, iodinated polypyrrole (I‐PPy) nanoparticles are fabricated via a one‐step synthesis strategy combining chemical oxidation and iodination for computed tomography (CT) imaging‐guided photothermal therapy. Iodic acid with a high standard electrode potential enables the chemical oxidation polymerization of pyrrole monomers. Meanwhile, the iodination of PPy induced by the corresponding reduction product I2 takes place during the polymerization process to generate I‐PPy nanoparticles. The prepared I‐PPy nanoparticles possess a uniform size, excellent colloidal stability, intense near‐infrared absorption, strong X‐ray attenuation ability, and favorable biocompatibility. The as‐synthesized I‐PPy nanoparticles not only guarantee remarkable contrast‐enhanced CT imaging of blood pool and tumors, but also realize effective tumor suppression in vitro and in vivo by I‐PPy nanoparticles‐mediated CT imaging‐guided photothermal therapy. To the best of the authors' knowledge, it is the first time that multifunctional PPy nanoparticles are fabricated through a one‐step synthesis process. The proposed strategy opens up a new way for the fabrication of high‐performance theranostic agents via a one‐step strategy under mild conditions.

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One-pot synthesis of albumin-gadolinium stabilized polypyrrole nanotheranostic agent for magnetic resonance imaging guided photothermal therapy

Cited by 64 publications

References 50 publications

Conjugated Polymer Materials for Photothermal Therapy

Conjugated Polymer Materials for Photothermal Therapy

Photothermal Composite Nanomaterials for Multimodal Tumor Therapy under MRI Guidance

One‐Step Synthesis of Iodinated Polypyrrole Nanoparticles for CT Imaging Guided Photothermal Therapy of Tumors

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