One‐Pot Synthesis of a New Series of 3‐Alkoxy‐5‐hydroxy‐5‐trifluoromethylpyrrolidin‐2‐ones from 1,1,1‐Trifluoro‐4‐alkoxyalk‐3‐en‐2‐ones.

Abstract

Trifluoro-4-alkoxyalk-3-en-2-ones. -Different substrates react with NaCN in an aqueous-alcoholic medium to yield highly functionalized title compounds, which may be of therapeutic value. -(ZANATTA*, N.; ROSA, L. S.; CORTELINI, M. F. M.; BEUX, S.; SANTOS, A. P. D.; BONACORSO, H. G.; MARTINS, M. A. P.; Synthesis 2002, 16, 2404-2408; Dep. Quim., Univ. Fed. Santa Maria, 97105 Santa Maria, Brazil; Eng.) -Mais 11-114