One-Pot Synthesis of 3-Oxocycloalka[c]pyridines

Sirakanyan, S. N.; Geronikaki, Athina; Карцев, В. Г.; Hakobyan, Elmira K.; Hovakimyan, Anush A.

doi:10.1134/s1070428021100250

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2023

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“…We synthesized terminal alkines from the 3(6)-hydroxy derivatives of cyclopenta[ c ]pyridine 1a [ 25 ], 5,6,7,8-tetrahydroisoquinolines 1b – d [ 25 ], pyrano [3,4- c ]pyridines 1e – g [ 14 , 26 ], and 2,7-naphtyridines 1h , i [ 27 ] to obtain the aimed hybrids, the 1,2,3-triazoles. It should be mentioned that tautomerism is possible in compound 1 lactam-lactim (NH/OH) via proton-migration of a hydrogen atom between the two basic centers.…”

Section: Resultsmentioning

confidence: 99%

New Bicyclic Pyridine-Based Hybrids Linked to the 1,2,3-Triazole Unit: Synthesis via Click Reaction and Evaluation of Neurotropic Activity and Molecular Docking

et al. 2023

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The synthesis of new original bicyclic pyridine-based hybrids linked to the 1,2,3-triazole unit was described via a click reaction. The anticonvulsant activity and some psychotropic properties of the new compounds were evaluated. The biological assays demonstrated that some of the studied compounds showed high anticonvulsant and psychotropic properties. The five most active compounds (7a, d, g, j, and m) contain a pyrano [3,4-c]pyridine cycle with a methyl group in the pyridine ring in their structures. Furthermore, molecular docking studies were performed, and their results are in agreement with experimental data.

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