“…The controllable electrophilic and nucleophilic properties make them as dual functionalized molecules, bringing about numerous applications in chemical transformations. 1,2 Significant progress has been made in the development of synthetic approaches for the construction of 1-iodoalkynes, including iodination of metal acetylides (Scheme 1, path a), 3 iodination of propiolic acid/trialkylsilylacetylides (path b), 4,5 a two-step homologation/iodination or elimination sequence from aldehydes or benzylic bromides (path c) 6,7 and direct iodination of terminal alkynes (path d). 8 Among these methods, the direct iodination of terminal alkynes is the most appealing strategy.…”