One pot synthesis of 1-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d] imidazoles in ionic liquids: Evaluation of antioxidant and antimicrobial activities

Seeka, Suresh; Narsimha, Sirassu; Battula, Kumaraswamy; Shaikh, A.H.; Tangeda, Savitha Jyostna; Nagavelli, Vasudeva Reddy

doi:10.5155/eurjchem.6.4.482-487.1325

Cited by 10 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seeka et al synthesized a novel series of benzimidazole-based 1,2,3-triazoles ( 15a–15n ) from N -propargyl benzimidazole, p -TsOH hydrate, aryl amines, and NaN 3 in [BMIM][PF 6 ]·H 2 O at room temperature via CuAAC (Scheme 15). 96 This method represents an highly efficient and benign approach for synthesizing 1,2,3-triazoles in good to excellent yields of 75%–95% using the [Bmim][PF 6 ]·H 2 O solvent system.…”

Section: Green Synthesis Of 123-triazolesmentioning

confidence: 99%

Ionic liquids for the green synthesis of 1,2,3-triazoles: a systematic review

Kumar,

Singh

et al. 2024

Green Chem.

View full text Add to dashboard Cite

show abstract

Section: Green Synthesis Of 123-triazolesmentioning

confidence: 99%

Ionic liquids for the green synthesis of 1,2,3-triazoles: a systematic review

Kumar,

Singh

et al. 2024

Green Chem.

View full text Add to dashboard Cite

show abstract

“…In recent years, chemical and biological usefulness of heterocyclic compounds attracted attention of chemist in form of pharmaceuticals, agrochemicals, polymers, dyes, etc . Triazole, a five‐membered heterocycle is key important, as its derivatives exhibited various biological activities such as antibacterial, antimalarial, antitubercular, anticancer, antiparasitic, antileishmanial, antioxidant, anti‐inflammatory, antidepressant, antiviral, etc. The 1,2,3‐triazole derivatives play an intriguing role in the development of new drugs, as effectively exerts various non‐covalent interactions which improves the solubility and the ability of binding to bimolecular targets …”

Section: Introductionmentioning

confidence: 99%

Synthesis, antibacterial, and antioxidant activities of naphthyl‐linked disubstituted 1,2,3‐triazoles

Kaushik

Luxmi

2020

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

Here, click synthesis of 15 naphthyl‐linked disubstituted 1,2,3‐triazoles has been carried out by the reaction between 1‐(prop‐2‐yn‐1‐yloxy)naphthalene and aromatic azides. The structure elucidation of the synthesized compounds was carried out by FTIR, 1H NMR, 13C NMR, and HRMS techniques. Further, the compound 7f was confirmed by X‐ray crystallography (CCDC 1876891). The synthesized compounds were explored for antibacterial activity against Bacillus cereus, Escherichia coli, and Staphylococcus aureus. Biological evaluation of synthesized 1,2,3‐triazoles revealed moderate to good antibacterial activity against the tested strains. The antioxidative behavior of synthesized compounds manifested the remarkable free radical scavenging activity using DPPH assay.

show abstract

Synthesis and Biological Evaluation of Novel Thiomorpholine 1,1-Dioxide Derived 1,2,3-Triazole Hybrids as Potential Anticancer Agents

et al. 2017

Self Cite

View full text Add to dashboard Cite

In this report, we describe the synthesis and biological evaluation of a new series of (4‐((1‐(aryl)‐1H‐1,2,3‐triazol‐4‐yl)methoxy)phenyl)(1,1‐dioxidothiomorpholino)methanone derivatives (6 a‐6 n). All the new derivatives were well analyzed by 1H NMR, 13C NMR, FTIR, mass spectral and elemental data. The synthesized compounds were screened for in vitro anticancer activity against three cancer cell lines (MCF‐7, HeLa, and HEK293) and compared with standard drug cisplatin. Three (6 b, 6 g and 6 i) out of fourteen derivatives exhibited potent anticancer activity against MCF‐7, HeLa, and HEK293. Two (6 b and 6 g) potent hybrids were screened for in vivo studies against EAC bearing mice and found to possess potential anticancer activity.

show abstract

One pot synthesis of 1-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d] imidazoles in ionic liquids: Evaluation of antioxidant and antimicrobial activities

Cited by 10 publications

References 32 publications

Ionic liquids for the green synthesis of 1,2,3-triazoles: a systematic review

Ionic liquids for the green synthesis of 1,2,3-triazoles: a systematic review

Synthesis, antibacterial, and antioxidant activities of naphthyl‐linked disubstituted 1,2,3‐triazoles

Synthesis and Biological Evaluation of Novel Thiomorpholine 1,1-Dioxide Derived 1,2,3-Triazole Hybrids as Potential Anticancer Agents

Contact Info

Product

Resources

About