2013
DOI: 10.7598/cst2013.39
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One Pot Synthesis, Characterisation and Antimicrobial Activity of α- Amino Phosphonates

Abstract: Abstract:The synthesis of some new α-amino phosphonates (4a-j) was accomplished by one pot reaction of equimolar quantities of 2-amino-4-chloro-5-nitro phenol (1), aromatic aldehydes (2a-j) and diethyl / dimethylphosphite (3) in dry tetrahydrofuran at reflux condition via Kabachnik -fields reaction in high yields. All the synthesized compounds were characterised by IR, 1 H, 13 C, 31 P NMR and examined for their antimicrobial activity and found to possess good activity.

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