One-pot synthesis and antiproliferative evaluation of pyrazolo[3,4-d]pyrimidine derivatives

Pyrimido[5,4-e]tetrazolo[5,1-b][1,3,4]thiadiazines as a new heterocyclic system

“…Keeping this in * Correspondent. E-mail: heshghi@um.ac.ir mind, and in continuation of our recent studies 11 on the enzyme inhibitory activity of pyrimido [5,4-e] [1,2,4]triazolo [3,4-b] - [1,3,4]thiadiazines against soybean 15-lipoxygenase, we considered the synthesis of pyrimidotetrazolothiadiazine compounds where the biologically active pyrimido[4,5-e]- [1,3,4]thiadiazine moiety is fused to a potent pharmacophoric tetrazole ring across the 6,7-positions.…”

Gold‐Catalyzed Synthesis of 1,3‐Diaminopyrazoles from 1‐Alkynyltriazenes and Imines

“…The primary amine group could be used to for further functionalization of the heterocycles. The group of Wong , for example, has shown that aminopyrazoles can be converted into biologically active pyrazolo‐pyrimidines by reaction with formamide in the presence of PBr 3 . Other transformations of aminopyrazoles include sulfonylation and acylation reactions, which were also carried out in the context of medicinal chemistry studies.…”

A Recent Update: Antimicrobial Agents Containing Pyrazole Nucleus

“…Recently, researcher's attention has been paid to heterocycles containing nitrogen atom, particularly pyrazoles and their derivatives [10]. They have been found to denote versatile biological activities such as monoamine oxidase inhibitor [11,12], antihepatotoxicity [13,14], antileishmanial [15][16][17], anti-inflammatory [18][19][20], antiproliferative [21], tissue non-specific alkaline phosphatase inhibitor [22], cyclin-dependent kinase inhibitor [23], anticancer [24][25][26][27], antimicrobial [28][29][30], and antioxidant [31][32][33]. Development of novel chemical structures of pyrazole derivatives is currently a trending topic due to their wonderful biological actions [34][35][36][37].…”