One-pot sequential coupling reactions as a new practical protocol for the synthesis of unsymmetrical 2,3-diethynyl quinoxalines and 4-ethynyl-substituted pyrrolo[1,2-a]quinoxalines

Recent Examples in the Synthesis and Functionalization of C−H Bonds in Pyrrolo/Indolo [1,2‐a]Quinoxalines

“…A multi‐component assembly for synthesis of 1,2,4‐tri‐substituted pyrrolo[1,2‐a]quinoxalines has been recently disclosed [27a] . This tactic was an extended version of the reaction scope of a known method with respect to C1 substituents [27b,c] .…”

Crystal structure, DFT studies, Hirshfeld surface and energy framework analysis of 4-(5-nitro-thiophen-2-yl)-pyrrolo [1, 2-a] quinoxaline: A potential SARS-CoV-2 main protease inhibitor

“…Pyrrolo [1, 2-a] quinoxalines, an important heterocyclic compound bearing quinoxaline moiety is characterized by a broad range of biological properties [11] . Derivatives of these tricyclic systems have received a great deal of attention for their miscellaneous use in the medicinal field as antileukemic [12] , anti-tuberculosis [13] , antimalarial [14] , anti–Leishmania [15] antidiabetic [ 16 , 17 ] and antibacterial [18] agents. Also, well-established evidence showed that several pyrrolo [1,2-a] quinoxaline-based compounds act as inhibitors against human protein kinase CK2, AKT kinase [19] .…”