One-pot reaction for the preparation of biofunctionalized self-assembled monolayers on gold surfaces

Iron-Based Metal–Organic Framework with Hydrophobic Quadrilateral Channels for Highly Selective Separation of Hexane Isomers

“…Here, we report the design and synthesis of a novel iron metal–organic framework {[Fe 3 (μ 3 -O)]­(6FDCA) 3 ·2DMF} ( 1 ) for the separation of hexane isomers. It is worth noting that the use of preformed building blocks [Fe 3 (μ 3 -O)­(CH 3 COO) 6 ] can address the issue of formation of unpredictable building blocks that commonly occurs in conventional one-pot reactions. − In addition, we anticipate that the selected linker with −CF 3 groups will increase the hydrophobicity of targeted MOFs as a result of high content of fluoro atoms …”

Local Cross-Coupling Activity of Azide-Hexa(ethylene glycol)-Terminated Self-Assembled Monolayers Investigated by Atomic Force Microscopy

“…The most commonly used reaction is copper­(I)-catalyzed azide-alkyne cycloaddition (CuAAC), which involves the reaction of a terminal alkyne, resulting in the formation of 1,4-disubstituted triazoles with a Cu­(I) catalyst . The CuAAC reaction offers several advantages in terms of speed, efficiency, pH independence, selectivity, stability of reactants and products, and bio-compatibility. ,, These attributes of click chemistry have led to its extensive applications in organic synthesis, ,, macromolecular formation, and bio-functionalization. ,− …”

“…Surface functionalization of metal surfaces with self-assembled monolayers (SAMs) ,, benefits significantly from click chemistry as it offers a more general and robust method of surface modification, thereby enabling a wide range of functionalities to be immobilized on the surfaces for applications in biosensors, biochips, antifouling interfaces nanomaterials, organic electronics, and electroactive surfaces. , Some notable applications of SAMs are in quartz crystal microbalance − and surface plasmon resonance sensor techniques, − which are powerful analytical methods for detecting and evaluating interactions of molecules on surfaces through the monitoring of mass changes per unit area and the refractive index of the surrounding media, , respectively. One of the most common SAMs that has gained significant recognition as a suitable molecular system for these applications is alkanethiol SAMs on a gold surface. ,, The structure of the SAMs on gold involves three components: a gold-sulfur bond that serves as the anchor point to the substrate, an alkyl chain that provides the driving force for self-assembly, and a terminal functional group that determines the chemical reactivity of the SAM surface by providing coupling sites for other molecules or compounds. ,, …”

“…Azide-terminated alkanethiol SAMs have been previously studied for surface modification via the CuAAC reaction with alkyne-bearing species. , Previous studies have reported CuAAC reactions for functionalizing azide-terminated-SAMs with ferrocene, peptides, ,,, polymers, , phenyl-capped bithiophene, and biotins . Owing to its strong potential for various surface chemistry applications, the azide-terminated SAMs can significantly control the structural and functional features of surfaces.…”

“…There is minimal information on the surface structures of N 3 -OEG-SAMs, particularly molecular-scale structures and features, which are important to understand surface reactivities. Typical characterizations employed in published works include spectroscopic methods, including nuclear magnetic resonance, infrared spectroscopy, ,, and absorption spectroscopy techniques. Meanwhile, in terms of microscopy analysis, scanning tunneling microscopy images, , as well as AFM images in air of only azide-terminated SAMs, have been reported; however, molecular-scale details of density, dynamics, and orientation of additional structures by cross-coupling reactions at the N 3 -OEG-SAM surfaces remain unclear.…”