One pot, rapid and efficient synthesis of water dispersible gold nanoparticles using alpha-amino acids

Wangoo, Nishima; Kaur, Sarabjit; Bajaj, Manish; Jain, Deepali; Sharma, Rohit K.

doi:10.1088/0957-4484/25/43/435608

Cited by 31 publications

(42 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S5A †) the absorbance is increased due to the reduction of the gold by medium constituents, e.g., by amino acids and glucose. 42,43 In the presence of serum proteins (DMEM with 1% FCS), a broad plasmon band with a maximum around 580 nm appears (solid line in Fig. S5A †), which can be explained by the reduction of HAuCl 4 in particular by the serum components.…”

Section: Intracellular Distribution Of In Situ Biosynthesized Nanostrmentioning

confidence: 94%

Properties of in situ generated gold nanoparticles in the cellular context

et al. 2017

View full text Add to dashboard Cite

Gold nanostructures that serve as probes for nanospectroscopic analysis of eukaryotic cell cultures can be obtained by the in situ reduction of tetrachloroauric acid (HAuCl). To understand the formation process of such intracellularly grown particles depending on the incubation medium, the reaction was carried out with 3T3 fibroblast cells in three different incubation media, phosphate buffer, Dulbecco's Modified Eagle Medium (DMEM), and standard cell culture medium (DMEM with fetal calf serum). The size, the optical properties, the biomolecular corona, and the localization of the gold nanoparticles formed in situ vary for the different conditions. The combination of surface-enhanced Raman scattering (SERS) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) microscopic mapping and transmission electron microscopy (TEM) provides complementary perspectives on plasmonic nanoparticles and non-plasmonic gold compounds inside the cells. While for the incubation with HAuCl in PBS, gold particles provide optical signals from the nucleus, the incubation in standard cell culture medium leads to scavenging of the toxic molecules and the formation of spots of high gold concentration in the cytoplasm without formation of SERS-active particles inside the cells. The biomolecular corona of nanoparticles formed in situ after incubation in buffer and DMEM differs, suggesting that different intracellular molecular species serve for reduction and stabilization. Comparison with data obtained from ready-made gold nanoparticles suggests complementary application of in situ and ex situ generated nanostructures for optical probing.

show abstract

Section: Intracellular Distribution Of In Situ Biosynthesized Nanostrmentioning

confidence: 94%

Properties of in situ generated gold nanoparticles in the cellular context

et al. 2017

View full text Add to dashboard Cite

show abstract

“…have been tested. Due to the biocompatible nature, easy accessibility, and remarkable reducing capabilities, the amino acids and their derivatives are used dominantly [60] to produce biocompatible noble metal NPs. As far as we know, to date, all the twenty naturally occurring amino acids were investigated.…”

Section: Preparation Of Amino Acid-reduced Colloidal Au Nps Havingmentioning

confidence: 99%

Reduction of Tetrachloroaurate(III) Ions With Bioligands: Role of the Thiol and Amine Functional Groups on the Structure and Optical Features of Gold Nanohybrid Systems

2019

View full text Add to dashboard Cite

In this review, the presentation of the synthetic routes of plasmonic gold nanoparticles (Au NPs), fluorescent gold nanoclusters (Au NCs), as well as self-assembled Au-containing thiolated coordination polymers (Au CPs) was highlighted. We exclusively emphasize the gold products that are synthesized by the spontaneous interaction of tetrachloroaurate(III) ions (AuCl4¯) with bioligands using amine and thiolate derivatives, including mainly amino acids. The dominant role of the nature of the applied reducing molecules as well as the experimental conditions (concentration of the precursor metal ion, molar ratio of the AuCl4¯ ions and biomolecules; pH, temperature, etc.) of the syntheses on the size and structure-dependent optical properties of these gold nanohybrid materials have been summarized. While using the same reducing and stabilizing biomolecules, the main differences on the preparation conditions of Au NPs, Au NCs, and Au CPs have been interpreted and the reducing capabilities of various amino acids and thiolates have been compared. Moreover, various fabrication routes of thiol-stabilized plasmonic Au NPs, as well as fluorescent Au NCs and self-assembled Au CPs have been presented via the formation of –(Au(I)-SR)n– periodic structures as intermediates.

show abstract

“…Water-dispersible semiconductor nanocrystals were developed for various important applications such as luminescent labeling agents in biological systems [ 1 , 2 , 3 ], photocatalysts for the hydrogen gas production by water splitting [ 4 , 5 , 6 ], and environmental purification agents to remove pollutants from wastewater by photodegradation reactions [ 7 , 8 , 9 ]. In the syntheses of the water-dispersible nanocrystals, several organic molecules such as sulfodiisooctyl succinate [ 10 ], mercaptoethanol [ 11 , 12 ], and conventional aminoacids [ 13 , 14 ] were found as effective surfactants to solubilize the originally hydrophobic semiconductor nanocrystals in water. However, the complicated surface properties of the nanocrystals dispersed in water have not been investigated in detail.…”

Section: Introductionmentioning

confidence: 99%

Surface Properties and Photocatalytic Activities of the Colloidal ZnS:Mn Nanocrystals Prepared at Various pH Conditions

Heo

Hwang

2015

Nanomaterials

View full text Add to dashboard Cite

Water-dispersible ZnS:Mn nanocrystals (NC) were synthesized by capping the surface with mercaptoacetic acid (MAA) molecules at three different pH conditions. The obtained ZnS:Mn-MAA NC products were physically and optically characterized by corresponding spectroscopic methods. The UV-Visible absorption spectra and PL emission spectra showed broad peaks at 310 and 590 nm, respectively. The average particle sizes measured from the HR-TEM images were 5 nm, which were also supported by the Debye-Scherrer calculations using the X-ray diffraction (XRD) data. Moreover, the surface charges and the degrees of aggregation of the ZnS:Mn-MAA NCs were determined by electrophoretic and hydrodynamic light scattering methods, indicating formation of agglomerates in water with various sizes (50–440 nm) and different surface charge values accordingly the preparation conditions of the NCs (−7.59 to −24.98 mV). Finally, the relative photocatalytic activities of the ZnS:Mn-MAA NCs were evaluated by measuring the degradation rate of methylene blue (MB) molecule in a pseudo first-order reaction condition under the UV-visible light irradiation. As a result, the ZnS:Mn-MAA NC prepared at the pH 7 showed the best photo-degradation efficiency of the MB molecule with the first-order rate constant (kobs) of 2.0 × 10−3·min−1.

show abstract

One pot, rapid and efficient synthesis of water dispersible gold nanoparticles using alpha-amino acids

Cited by 31 publications

References 32 publications

Properties of in situ generated gold nanoparticles in the cellular context

Properties of in situ generated gold nanoparticles in the cellular context

Reduction of Tetrachloroaurate(III) Ions With Bioligands: Role of the Thiol and Amine Functional Groups on the Structure and Optical Features of Gold Nanohybrid Systems

Surface Properties and Photocatalytic Activities of the Colloidal ZnS:Mn Nanocrystals Prepared at Various pH Conditions

Contact Info

Product

Resources

About