One-pot preparation of a novel monolith for high performance liquid chromatography applications

Xiao-yan, Jiao; Shen, Shigang; Shi, Tiesheng

doi:10.1016/j.jchromb.2015.10.028

Cited by 10 publications

(2 citation statements)

References 63 publications

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“…17 For surface modification, the use of 2,3-epoxypropyl methacrylate (GMA) copolymers has been continuously growing, due to their successful applications in various process. [18][19][20][21] Copolymers of GMA are commercially available, bearing reactive oxirane groups. These oxirane groups present in the polymer chain can easily undergo an opening reaction with nucleophilic reagents that contain hydroxyl, carboxyl or amine groups.…”

Section: Introductionmentioning

confidence: 99%

Surface Modification of Poly(GMA-co-EDMA-co-MMA) with Resorcarenes

Castillo-Aguirre¹,

Velásquez-Silva²,

Palacio³

et al. 2018

J. Braz. Chem. Soc.

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Surface modification of poly(GMA-co-EDMA-co-MMA), whose synthesis was performed by copolymerization of 2,3-epoxypropyl methacrylate (GMA), methyl methacrylate (MMA), and ethylene glycol dimethacrylate (EDMA), was compared between aliphatic and aromatic substituted resorcarenes. The copolymer surface was modified by reacting with resorcarenes, and the vibrational properties of the modified copolymers were investigated via attenuated total reflectance Fourier transform infrared (ATR-FTIR) and Raman spectroscopies in dry state at room temperature. Those analysis showed that only tetra(p-hydroxyphenyl)resorcarene was linked to the copolymer, the reaction was regioselective with the crown conformer. Additionally, quantification of incorporated macrocyclic was performed, specifically, the maximum fixation of resorcarene in the copolymer was 95% when employing two molar resorcarene excesses per glycidyl residue.The modification was carried out in both acidic and basic medium and it was established that the polymer is modified with the aromatic resorcarene only in basic medium, while the reaction in basic medium with aliphatic resorcarenes produces their corresponding tetrasodium salt.

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Section: Introductionmentioning

confidence: 99%

Surface Modification of Poly(GMA-co-EDMA-co-MMA) with Resorcarenes

Castillo-Aguirre¹,

Velásquez-Silva²,

Palacio³

et al. 2018

J. Braz. Chem. Soc.

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“…The stretching band at 1271 cm -1 and 1193 cm -1 indicate the presence of C-O-C. The absorbance peak was present at 2977 cm -1 due to the -Ch3 group [21].…”

Section: Ftir Spectroscopy Datamentioning

confidence: 98%

Study on The Emulsion Stability of Tripropylene Glycol Diacrylate in Water

Shirajuddin,

Al Bakri Abdullah,

Ghazali

et al. 2023

Archives of Metallurgy and Materials

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Study on the emulSion Stability of tripropylene Glycol diacrylate in WaterOil-in-water emulsion is thermodynamically unstable system that undergoes destabilization with time. The tripropylene glycol diacrylate (TPGda) monomer which can potentially to increase the crosslink density of polymer blends is unstable in water due to its low water solubility properties. however, the stability of TPGda emulsion could be improved by adding an adequate amount of surfactant. This study addresses the effect of different Tween 20 (surfactant) concentration on emulsion stability of TPGda. Model emulsion ranging between 0.1 wt% to 3 wt% of Tween 20 and a control were prepared using heavy duty homogenizer. The emulsion was characterised by FTir, microstructure analysis, phase separation observation and creaming index during storage time. Emulsion containing 0.4 wt% Tween 20 showed the longest stability at 24 hours and a creaming index of 0%, which is enough for an ideal emulsion. The FTir spectra displayed the interaction of TPGda and Tw-20, proving that the emulsion is fully mixed and stabilized. The results are further supported by optical microscopy, which observed no droplet aggregation and flocculation in the TPGda emulsion with the presence of 0.4 wt% of Tw-20 surfactant. This information about Tw-20 is beneficial, making it a promising surfactant for enhancing the emulsion stability of the TPGda emulsion.

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Monolithic High‐Performance Liquid Chromatography Columns

Desire

Hilder

Arrua

2017

Encyclopedia of Analytical Chemistry

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Monolithic HPLC (high‐performance liquid chromatography) columns have emerged over the recent decades as highly attractive alternatives to conventional HPLC technology. A monolith is considered to be a continuous piece of porous material. Two types of monolithic columns have been developed for liquid chromatography (LC) applications; they are polymer monoliths and silica monoliths, which differ based on their porous properties. Polymer monoliths consist solely of macropores (pores larger than 50 nm), while silica monoliths possess both macropores and mesopores (pores between 2 and 50 nm). Silica monoliths therefore possess higher surface areas than polymer monoliths and have mainly been utilied for the separation of small molecules, where excellent separation performance has been demonstrated. Polymer monoliths on the other hand have been shown to provide excellent separation performance for larger molecules, where the convective transport of these molecules is unhindered by the presence of mesopores. Polymer and silica monoliths can be prepared in a variety of ways, resulting in varied surface chemistries and flow properties, thus allowing their application in a wide range of chromatographic modes, including reversed‐phase (RP), ion‐exchange, hydrophilic interaction, and hydrophobic interaction chromatography (HIC), to name a few. This has allowed for the separation of a variety of analytes, from small molecules such as alkylbenzenes, to larger molecules such as peptides and proteins. They have also found application for the separation of DNA. In recent years, significant attention has been focused on improving and understanding the behavior of these materials and alternative synthetic routes for their preparation.

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One-pot preparation of a novel monolith for high performance liquid chromatography applications

Cited by 10 publications

References 63 publications

Surface Modification of Poly(GMA-co-EDMA-co-MMA) with Resorcarenes

Surface Modification of Poly(GMA-co-EDMA-co-MMA) with Resorcarenes

Study on The Emulsion Stability of Tripropylene Glycol Diacrylate in Water

Monolithic High‐Performance Liquid Chromatography Columns

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