One‐Pot Multicomponent Synthesis of Indoles from 2‐Iodobenzoic Acid

Reactivity of tetrahydrochromeno[2,3‐b]indoles: chromic indicators of cyanide

“…The combined extracts were washed 1× NaHCO 3 (aq) and 1× H 2 O. The organic phase was dried over MgSO 4 and volatiles removed in vacuo to afford 3.43 g (90% yield) of 2,3,4,9‐tetrahydro‐1H‐carbazole which was used without further purification. Using the general alkylation procedure, 9‐methyl‐2,3,4,9‐tetrahydro‐1H‐carbazole and matched literature data The product was used without purification.…”

Recent advances in the synthesis of indoles from alkynes and nitrogen sources

“…Under these conditions, ortho-iodobenzoic acid was converted to indole derivatives 223 by a one-pot Curtius rearrangement 210 /palladiumcatalyzed indolization process (Scheme 180). 211 In this synthetic strategy, the ortho-iodoaniline and sodium chloride, which are essential for the cyclization, are produced in situ as by-products of the Curtius rearrangement. In addition, when an acylating agent was added under the reaction conditions, indole N-carboxamide derivatives 224 were produced (Scheme 180).…”

Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade

“…Further indole syntheses by multi-component reactions are a new 3CR Fischer indole syntheses based on new reactions of organometallic reagents with nitriles and carboxylic acids, which extend scope and synthetic utility of these syntheses [ 48 ], MCR of indoles from 2-iodobenzoic acid [ 49 ], and highly diversified indole scaffolds by U-4CR [ 50 ].…”