One-pot multicomponent synthesis of indol-3-yl-hydrazinyl thiazoles as antimicrobial agents

Mahmoodi, Nosrat O.; Khalili, Behzad; Rezaeianzade, Olia; Ghavidast, Atefeh

doi:10.1007/s11164-016-2478-y

Cited by 24 publications

(10 citation statements)

References 48 publications

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“…In our recent study, it was observed that benzyl linkage has a potent influence on the antibacterial activity. Similar results were observed in this study for products 6i and 6l . Moreover, the only structural difference between these isomers ( 6i and 6l) is the linkage position on the benzyl ring, namely para and meta connections, respectively.…”

Section: Resultssupporting

confidence: 90%

“…Encouraged by all of the above, as well as the limited studies on the synthesis of bis‐thiazoles in the literature, and in continuation of our ongoing research program on the synthesis of mono‐ and bis‐thiazoles and screening for their biological activities, we report in this paper the one‐pot semi‐five‐component, efficient, and rapid method for the synthesis of new bis‐thiazoles and screening otheir antibacterial and antioxidant activities.…”

Section: Introductionmentioning

confidence: 98%

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Sequential one‐pot multicomponent synthesis of bis‐aminothiazols and evaluation of their antibacterial and antioxidant activities

Parvizi

Mahmoodi

Pirbasti

2018

J Chinese Chemical Soc

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A series of novel bis-thiazoles were synthesized through a one-pot semi-fivecomponent reaction of the prepared α-bisbromo ketones, aldehydes, and thiosemicarbazide in the presence of p-TsOH under reflux condition. Products were obtained in reasonable yields via an efficient, convenient, and simple setup. The inhibitory activity on bacterial growth of the products was studied against Gramnegative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacterial strains (Micrococcus luteus, Staphylococcus aureus) at different concentrations (25, 50, 100, and 200 μg/mL at 600 nm). Most of the products showed inhibitory activity at the concentration of 200 μg/mL. In addition, bis-thiazoles showeed high to moderate antioxidant activity using the diphenylpicrylhydrazyl (DPPH) method. Bis-thiazoles 6i and 6j showed higher antioxidant activity than vitamin C and vitamin E.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 98%

Sequential one‐pot multicomponent synthesis of bis‐aminothiazols and evaluation of their antibacterial and antioxidant activities

Parvizi

Mahmoodi

Pirbasti

2018

J Chinese Chemical Soc

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“…71 The products were evaluated for in vitro antibacterial activity against Gram-positive and Gramnegative bacteria. Some of the products have good antibacterial activity.…”

mentioning

confidence: 99%

Recent advances in the application of indoles in multicomponent reactions

2018

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Indoles are some of the most versatile and common nitrogen-based heterocyclic scaffolds and are frequently used in the synthesis of various organic compounds. Indole based compounds are very important among heterocyclic structures due to their biological and pharmaceutical activities. The last decade, in particular, has witnessed considerable activity towards the synthesis of indole derivatives due to the possibilities for the design of polycyclic structures by the incorporation of multiple fused heterocyclic scaffolds in an attempt to achieve promising new heterocycles with chemical and biomedical relevance. In this study, we provide an overview on recent applications of indole in the multicomponent reactions for the synthesis of various heterocyclic compounds during the period of 2012 to 2017.

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“…This work was part of our interest in the study and synthesis of heterocyclic compounds . For simplification, the final triazepine products were categorized in four triazepine categories, namely TAP‐1,2,3, TAP‐1,2,4, TAP‐1,2,5, and TAP‐1,3,5.…”

Section: Discussionmentioning

confidence: 99%

Overview on Developed Synthesis Methods of Triazepane Heterocycles

Zeydi

2017

J Chinese Chemical Soc

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Triazepanes are important seven‐membered heterocyclic compounds with nitrogen at different positions in the ring, and have many pharmaceutical activities. Compounds with the triazepane core have attracted much attention as a result of their interesting biological properties. A study of the literature shows that there are various methods for the preparation of triazepanes. In this review, we have classified the methods based on the nitrogen position in the final triazepine products into four triazepine classes, namely TAP‐1,2,3, TAP‐1,2,4, TAP‐1,2,5, and TAP‐1,3,5.

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One-pot multicomponent synthesis of indol-3-yl-hydrazinyl thiazoles as antimicrobial agents

Cited by 24 publications

References 48 publications

Sequential one‐pot multicomponent synthesis of bis‐aminothiazols and evaluation of their antibacterial and antioxidant activities

Sequential one‐pot multicomponent synthesis of bis‐aminothiazols and evaluation of their antibacterial and antioxidant activities

Recent advances in the application of indoles in multicomponent reactions

Overview on Developed Synthesis Methods of Triazepane Heterocycles

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