One‐pot multicomponent synthesis and antimicrobial evaluation of novel tricyclic indenopyrimidine‐2‐amines

Abstract

The synthesis of novel tricyclic indenopyrimidine-2-amines from 3,3-dimethyl-/3methyl-2H-indanones has achieved by base-catalyzed one-pot three-component reaction. The desired products are formed within 10 hours after addition at reflux temperature. This multicomponent approach offers a viable protocol for the construction of indenopyrimidine-2-amines in single-step without the isolation of the intermediates 3,3-dimethyl/3-methyl-2-(4-substituted benzylidene)-2,-3-dihydro-1H-inden-1-ones. All the synthesized compounds have been screened for antimicrobial activity and some of the derivatives show comparable activity against bacterial and fungal isolates.

Pyrazole‐Clubbed Piperazinyl Urea Derivatives: Synthesis, Characterization and Antimicrobial Studies toward Generating an Antibiotic/Antifungal Resistance Sensor

“…[33] Due to exhibiting a wide range of approved biological activities, the flourishment of new chemical entities (NCE's) possessing pyrazole ring has very much attracted researchers over the past several decades. [34][35][36][37][38][39][40] Due to excellent results obtained using molecular-hybrid approach and significance of hybrid molecules in various biological fields, and in continuation of our research program aimed at the synthesis of a variety of biological important heterocyclic compounds, [41][42][43][44][45][46] we report herein an efficient and practically feasible synthesis, characterization and antimicrobial evaluation of novel pyrazole-clubbed piperazinyl urea derivatives. Based on antimicrobial evaluation, current-voltage (IV) studies were carried out to see the feasibility for generating futuristic antibiotic/antifungal resistance sensor.…”

Urea derivatives of piperazine doped with pyrazole‐4‐carboxylic acids: Synthesis and antimicrobial evaluation

“…Owing to the findings regarding the urea and piperazine based compounds and continuation of our research work aimed at the synthesis of a variety of heterocyclic systems for biological and pharmacological evaluations [28][29][30][31][32][33], we report in the present work an efficient synthesis and antimicrobial evaluation of N-cycloalkyl/aryl-4-(1,3-diphenyl-1H-pyrazole-4-carbonyl)piperazine-1-carbox amide derivatives.…”