One-pot, four-component synthesis of benzylpyrazolyl naphthoquinone derivatives and molecular docking studies

Lakshmanan, Sivalingam; Ramalakshmi, N.

doi:10.1080/00397911.2016.1244693

Cited by 13 publications

(8 citation statements)

References 28 publications

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“…Comparative analysis of the present protocol revealed the superiority of the present catalysts as compared to other reported protocols with respect to time required for competition of the reaction, conditions and yields. 133 134 135 136…”

Section: Aza- and Oxa-heterocycle Synthesis Catalysed By Mnpsmentioning

confidence: 99%

Synthesis of Nitrogen- and Oxygen-Containing Heterocycles Catalysed by Metal Nanoparticles Reported in 2022

Dhameliya,

Shah,

Shah

et al. 2024

Synlett

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The versatility of aza- and oxa-heterocyclic compounds has garnered significant attention in recent times. A large number of currently approved pharmaceutical products include nitrogen- and oxygen-containing heterocycles. Recent nanotechnological developments have propelled an upsurge in the applications of nanocatalysis for heterocyclic synthesis. Metal nanoparticles (MNPs) have emerged as promising catalysts for the synthesis of aza- and oxa-heterocycles owing to their unique physicochemical properties. Various MNPs including gold, silver, nickel and palladium have been evaluated for their catalytic activities in different reaction types, including cyclisation, coupling, hydrogenation and oxidative transformations. The MNPs have exhibited remarkable catalytic efficiency when utilised under optimal conditions. These catalysts have showcased high reusability and recyclability, yielding satisfactory amounts of the desired heterocyclic compound. The present work provides a detailed overview of recent advances in the area of MNP-assisted synthetic construction of aza- and oxa-heterocycles, published during the previous calendar year, 2022. The review serves as a valuable resource and also paves the way for future investigations in the development of novel catalytic strategies for heterocycle synthesis.1 Introduction2 Nanocatalysis3 Aza- and Oxa-Heterocycle Synthesis Catalysed by MNPs3.1 AuNPs3.2 CuNPs3.3 CoNPs3.4 FeNPs3.5 NiNPs3.6 PdNPs3.7 PtNPs3.8 SiNPs3.9 ZnNPs3.10 Bimetallic NPs3.11 Other MNPs4 Summary and Outlook

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Section: Aza- and Oxa-heterocycle Synthesis Catalysed By Mnpsmentioning

confidence: 99%

Synthesis of Nitrogen- and Oxygen-Containing Heterocycles Catalysed by Metal Nanoparticles Reported in 2022

Dhameliya,

Shah,

Shah

et al. 2024

Synlett

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“…Organic & Biomolecular Chemistry radiation using a variety of aldehydes, 5-amino-pyrazoles, isocyanides, dialkyl acetylenedicarboxylates, and a catalytic amount of p-toluenesulfonic acid where fully decorated pyrroles were produced with high chemoselectivity and excellent product yields. It has been assumed that the mechanism comprised successive domino processes, including imination, nucleophilic addition, and dipolar cyclization, followed by tandem [1,5]-H migration.…”

Section: Reviewmentioning

confidence: 99%

“…46 Consequently, a hybrid molecular structure containing chromene and other biologically active heterocycles may lead to the development of molecules of biological and pharmacological importance. In view of the significance of chromene annelated heterocycles, many )-dione and naphthalen-2-ol to produce a series of benzo [5,6]chromeno [3,2-c]quinolone derivatives in aqueous ethanol medium (Scheme 32). 47 A high yield of products (up to 92%) was isolated within 1-2 hours under reflux conditions.…”

Section: Synthesis Of Chromene Derivativesmentioning

confidence: 99%

p-Toluenesulfonic acid-promoted organic transformations for the generation of molecular complexity

Pal,

Das,

Bhunia

2024

Org. Biomol. Chem.

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Section: Synthetic Developments On 2-hydroxy-14-naphthoquinonementioning

confidence: 99%

“…Benzylpyrazolyl naphthoquinone derivatives hold significant importance as they are found in numerous natural products including atovaquone, lapachol, parvaquone, and buparvaquone. 64 These derivatives have demonstrated diverse biological activities such as antibacterial, anti-HIV, antiviral, anticoagulant, antioxidant, and anticancer properties. 65 Patil et al 66 presented a green and cost-effective method for synthesizing benzylpyrazolyl naphthoquinone in water at room temperature, utilizing -CD-SO 3 H as a catalyst.…”

Section: Benzylpyrazolyl Naphthoquinone Derivativesmentioning

confidence: 99%

Recent Advances in the Synthesis of 2-Hydroxy-1,4-naphthoquinone (Lawsone) Derivatives

Sagar,

Shankar,

Khanna

et al. 2023

SynOpen

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Lawsone, also known as 2-hydroxy-1,4-naphthoquinone, has been extensively studied and found to be a crucial precursor in the production of a diverse range of natural products like molecular scaffolds, which are highly sought after for biological research purposes. Due to its unique chemical composition, Lawsone has been utilized for over a century as a starting material for the synthesis of numerous biologically active molecules and materials, showcasing intriguing properties across a wide range of scientific and technological applications. Additionally, Lawsone has been widely used in organic synthesis processes, with its various applications. The recent advances in the synthesis of different scaffolds starting from Lawsone and their applications are being discussed in details in the current review covering the literature during the period of 2017-2023.

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One-pot, four-component synthesis of benzylpyrazolyl naphthoquinone derivatives and molecular docking studies

Cited by 13 publications

References 28 publications

Synthesis of Nitrogen- and Oxygen-Containing Heterocycles Catalysed by Metal Nanoparticles Reported in 2022

Synthesis of Nitrogen- and Oxygen-Containing Heterocycles Catalysed by Metal Nanoparticles Reported in 2022

p-Toluenesulfonic acid-promoted organic transformations for the generation of molecular complexity

Recent Advances in the Synthesis of 2-Hydroxy-1,4-naphthoquinone (Lawsone) Derivatives

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