One-pot facile synthesis of novel 1,2,3-triazole-appended α-aminophosphonates

[Et3NH][HSO4] catalyzed solvent‐free synthesis of new 1,2,3‐triazolidene‐indolinone derivatives

“…[ 61 ] Also, the ether derived from 1,2,3‐triazole aldehyde has been shown as significant activity against P2X7R receptor. [ 62 ] Recently, we have reported the use of triazolyl aldehydes for the synthesis of triazole‐chromene conjugates, [ 63 ] 1,2,3‐triazolyl pyrano pyrazoles, [ 64 ] 1,2,3‐triazole appended α‐aminophosphonates, [ 49 ] triazole‐biscoumarin conjugates, [ 65 ] and triazole‐diindolylmethane conjugates [ 66 ] as an antioxidant, antitubercular, and antifungal agents (Scheme 1).…”

“…In our continued efforts to exploit 1,2,3‐triazole as the bio‐potential pharmacophore in the synthesis of a wide range of heterocyclic scaffolds with diverse biological activities, [ 47–55 ] herein we would like to report [Et 3 NH][HSO 4 ] ionic liquid as green reaction media and catalyst for the synthesis of new 1,2,3‐triazolidene‐indolinone derivatives. To the best of our knowledge, there seem to be no reports on the synthesis of arylidene‐indolinones via Knoevenagel condensation.…”

Naphthalen-2-yl 1-(benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate

“…Recently, the work of Ming-Jie Chu [26] showed an increased efficacy of 1,2,3 triazole derivatives containing the pyrazole ester as inhibitors of topoisomerase II. In addition, some aminophosphonates containing the triazole ring were synthesized [27][28][29]. They have been the subject of the study of their pharmacological activities such as in the work of Ouahrouch et al [30] and Makaro et al [31] on the cytotoxicity of cancer cells.…”

Synthèse Et Caractérisation De La Structure Du [{4-[(1HBenzo[D]Imidazol-1-Yl)Méthyl]- 1H-1,2,3-Triazol-1 Yl}(Benzamido)Méthyl]Phospho nate De Diéthyle Par La Spectroscopie RMN 1D Et 2D

“…Cette large gamme d'activités thérapeutique et pharmacologique (Shaikh et al, 2020) encourage les chercheurs à développer de nouvelles méthodes de synthèse d'α-aminoacides phosphoniques (Orsini et al, 2010), dont les principales voies sont la réaction one-pot de kabachnick-Fields (Cherkasov et al, 1998-Danne et al,2018…”