One-pot facile preparation of PEG-modified PLGA nanoparticles: Effects of PEG and PLGA on release properties of the particles

Yoneki, Nao; Takami, Taku; Ito, Tomoki; Anzai, Ryosuke; Fukuda, Kengo; Kinoshita, Keiji; Sonotaki, Seiichi; Murakami, Yoshihiko

doi:10.1016/j.colsurfa.2015.01.011

Cited by 29 publications

(14 citation statements)

References 34 publications

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“…PBS is basically considered as a hydrophobic material and therefore its modification with hydrophilic polymers could expand the possible applications of this green polymer in the microencapsulation area. In that sense, polyethylene glycol (PEG) could be a good candidate because of its high hydrophilicity that could significantly alter the release rate of the encapsulated substance and specially charged drugs …”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of PEG‐PBS Copolymers to Obtain Microspheres With Different Naproxen Release Profiles

Ramón

Sáez²,

Gomes³

et al. 2018

Macromolecular Symposia

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Researching for new biomaterials intended for drug delivery systems has considerably intensified in recent years. There is an increasing interest in PBS (poly[butylene succinate]) and its copolymers as biomaterials due to the possibility of synthesis of the PBS from a renewable source. Among these copolymers, PBS‐PEG (poly[butylene succinate‐co‐polyethylene glycol]) is studied for materials that have shape memory and are biodegradable. However, to date, no research into the use of PBS‐PEG to prepare microspheres for drugs release has been reported. Herein, PBS‐PEGs with three PEG with different chain′s length were synthesized by polycondensation reaction and characterized by means of SEC, FTIR, DSC, TGA, and DRX. Naproxen loaded microspheres were prepared by an oil‐in‐water (o/w) single emulsion technique. The drug release was followed by UV‐Vis. The presence of PEG had a marked effect on the in vitro release profiles. The mathematical models employed show that the fundamental mechanism of release is diffusion when PEG is present in the polymer matrix of the particle.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of PEG‐PBS Copolymers to Obtain Microspheres With Different Naproxen Release Profiles

Ramón

Sáez²,

Gomes³

et al. 2018

Macromolecular Symposia

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“…The PLGA-PEG diblock copolymer was synthesized by conjugating NH 2 -PEG-COOH with PLGA-COOH through 1-ethyl- The preparation is according to a previously reported method with some modifications. 23 Briefly, 200 mg PLGA-COOH was dissolved in 10 mL DCM under magnetic stirring at room temperature. Then, 1 mg 4-dimethylaminopyridine (DMAP) was added, followed by addition of 2.9 mg EDC and 1.8 mg NHS to create PLGA-NHS.…”

Section: Synthesis Of Copolymer Plga-pegmentioning

confidence: 99%

High-performance reoxygenation from PLGA-PEG/PFOB emulsions: a feedback relationship between ROS and HIF-1α

Wang¹,

Wang²,

Li³

et al. 2018

IJN

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BackgroundHypoxemia is one of the most common pathological processes in various clinical diseases.MethodsA novel emulsion of poly(lactide-co-glycolide)-poly(ethylene glycol)/perfluorooctyl bromide has been developed to improve arterial hypoxemia through pulmonary drug delivery. Hypoxia-reoxygenation experiment was used to investigate the ability of the emulsion to supply oxygen and the saline lavage acute lung injury model was established to evaluate oxygen supply of the emulsion.ResultsIt has been demonstrated that an apparent increase has been detected in the cytotoxicity test of the emulsion, indicating its lower cell toxicity. A hypoxia-reoxygenation experiment uncovered the fact that notable cell growth was observed after reoxygenation with poly(lactide-co-glycolide)-poly(ethylene glycol)/perfluorooctyl bromide emulsion because of the ability of the emulsion to supply oxygen adequately and reasonably. Moreover, the level of intracellular reactive oxygen species was significantly enhanced during hypoxia, which further influenced the concentration and activity of hypoxia-inducible factor-1α (HIF-1α). Furthermore, the upregulated expression of HIF-1α during hypoxia has verified that certain emulsions can increase HIF-1α content and relieve hypoxia, which further indicates HIF-1α plays an essential role in improving cell viability. Afterwards, the saline lavage acute lung injury model was established to evaluate oxygen supply of the emulsion and the result shows considerable improvement of lung ventilation of rabbits.ConclusionWe recommend that the feedback relationship between reactive oxygen species and HIF-1 plays an essential role in improving cell viability. It is anticipated that the emulsion will be applied in the field of alleviating hypoxemia.

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“…The controlled sustained release of compounds from hydrogels is difficult because the release mechanism depends mainly on two phenomena: the degradation of polymeric networks and the diffusion of compounds through the hydrogel medium. In these regards, we have developed a novel ‘hybrid’ approach: the incorporation of functional block copolymers and/or their self-assembly (polymeric micelles) into base materials (such as gel [ 3 , 4 , 5 , 6 , 7 ], sheets [ 8 , 9 , 10 ], and particles [ 11 , 12 , 13 , 14 , 15 ]) for the construction of biomaterials for drug delivery systems. Polymeric micelles have a core that can incorporate either hydrophobic [ 16 , 17 , 18 , 19 , 20 , 21 ] or hydrophilic [ 22 , 23 ] compounds and release drugs by means of either the dilution-induced collapse or the degradation of micelle-forming polymers.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Gel Sheet Containing Polymeric Micelles: Synthesis and Gelation Properties of PEG-Grafted Chitosan

et al. 2017

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Wound-dressing sheet biomaterials can cover wound sites and enhance wound healing. In this study, a detailed evaluation of the factors affecting both the PEG modification percentage (PMP) in poly(ethylene glycol) (PEG)-grafted chitosan synthesis and the gelation properties of PEG-grafted chitosan was presented for constructing our novel hybrid hydrogel sheet consisting of PEG-grafted chitosan (a gel-forming polymer) and a reactive polymeric micelle (a crosslinker). It was confirmed that various factors (i.e., the weight ratio of PEG/chitosan, the pH of the buffer solution, reaction times, and reaction temperatures) in the preparation stage of PEG-grafted chitosans affected the PMP of PEG-grafted chitosans. Furthermore, the PMP of PEG-grafted chitosans affected their gelation properties. Finally, a 'flexible' hydrogel sheet that can be reversibly dried and moistened was successfully obtained. The dried rigid, thin sheet is expected to be suitable for stable preservation. The results obtained in this paper show that the incorporation of drug carriers into biomaterials is a novel approach to improve functionality.

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One-pot facile preparation of PEG-modified PLGA nanoparticles: Effects of PEG and PLGA on release properties of the particles

Cited by 29 publications

References 34 publications

Synthesis and Characterization of PEG‐PBS Copolymers to Obtain Microspheres With Different Naproxen Release Profiles

Synthesis and Characterization of PEG‐PBS Copolymers to Obtain Microspheres With Different Naproxen Release Profiles

High-performance reoxygenation from PLGA-PEG/PFOB emulsions: a feedback relationship between ROS and HIF-1α

Chitosan Gel Sheet Containing Polymeric Micelles: Synthesis and Gelation Properties of PEG-Grafted Chitosan

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One-pot facile preparation of PEG-modified PLGA nanoparticles: Effects of PEG and PLGA on release properties of the particles

Cited by 29 publications

References 34 publications

Synthesis and Characterization of PEG‐PBS Copolymers to Obtain Microspheres With Different Naproxen Release Profiles

Synthesis and Characterization of PEG‐PBS Copolymers to Obtain Microspheres With Different Naproxen Release Profiles

High-performance reoxygenation from PLGA-PEG/PFOB emulsions: a feedback relationship between ROS and HIF-1&alpha;

Chitosan Gel Sheet Containing Polymeric Micelles: Synthesis and Gelation Properties of PEG-Grafted Chitosan

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High-performance reoxygenation from PLGA-PEG/PFOB emulsions: a feedback relationship between ROS and HIF-1α