One‐Pot Fabrication of a Novel Agar‐Polyacrylamide/Graphene Oxide Nanocomposite Double Network Hydrogel with High Mechanical Properties

Zhu, Pang; Meng, Hu; Deng, Yonghong; Wang, Chaoyang

doi:10.1002/adem.201600272

Cited by 63 publications

(36 citation statements)

References 48 publications

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“…1.2% GO/polyacrylamide hydrogel for peripheral nerve regeneration (tension) [46] 38 MPa N/A N/A Skin [152] 1-30 MPa 15-150 MPa 30-115 1 wt% GO/PVA for load-bearing tissue substitutes (compression) [135] 17 MPa 60 kPa N/A 0.1 wt% GO/PVA (compression) [38] 2.8 MPa N/A N/A 1 wt% GO/cellulose/PVA (tension) [39] 0.73 MPa N/A 240 1 mg ml À1 GO/carboxymethyl chitosan/KGM for wound dressing (compression) [48] 208 kPa 1.11 MPa N/A GO/polyacrylamide/agar (compression) [122] 332 kPa N/A 4600 2 mg ml À1 GO/GelMa hydrogel for cardiac patches (tension) [47] 977 kPa 24 kPa 55 1 mg ml À1 GO/gelatin hydrogel for muscle tissue engineering (rheometry measurement) [102] N/A 3.42 kPa N/A www.advancedsciencenews.com www.aem-journal.com engineering applications. The incorporation of GO in polymer was found to improve the physical and biological properties of the composites.…”

Section: Discussionmentioning

confidence: 99%

“…A compressive strength of 656 MPa was obtained for the GOincorporated hydrogels. Moreover, Zhu et al [122] incorporated agar into the GO/polyacrylamide hydrogels. Agar hydrogels have a high elastic modulus; however, they are brittle.…”

Section: Polyacrylamidementioning

confidence: 99%

“…Figure 8 shows the GO/sodium alginate/polyacrylamide hydrogels without and with pressure and the GO/polyacrylamide hydrogels under different modes of stress. [136,122] Figure 8 demonstrates that polyacrylamide hydrogels may have very different mechanical properties. Blending polyacrylamide with alginate, a very high strength was achieved and with addition of agar, a very high elongation at break could be maintained which can withstand different stress modes.…”

Section: Polyacrylamidementioning

confidence: 99%

“…GO/agar/polyacrylamide hydrogels which can withstand c) winding, d) knotting e) knot stretching, f) twisting, and g and h) free shapeable properties (reproduced with permission from ref. [122] 2016 Wiley).…”

Section: Plla 3d Porous Scaffoldsmentioning

confidence: 99%

“…[116][117][118] Some other very rarely studied synthetic polymers for potential biomedical sciences are poly(carbonate urethane), [119] poly(acrylic acid), [92] poly(l-lysine), [120] and elastomers. [121][122][123] 2.2.1. PVA PVA is a biocompatible, highly hydrophilic, water-soluble, and biodegradable synthetic polymer that is widely studied in the biomedical field.…”

Section: Synthetic Polymersmentioning

confidence: 99%

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Graphene Oxide/Polymer‐Based Biomaterials

2017

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Since its discovery in 2004, derivatives of graphene have been developed and heavily investigated in the field of tissue engineering. Among the most extensively studied forms of graphene, graphene oxide (GO), and GO/ polymer-based nanocomposites have attracted great attention in various forms such as films, 3D porous scaffolds, electrospun mats, hydrogels, and nacre-like structures. In this review, the most actively investigated GO/ polymer nanocomposites are presented and discussed, these nanocomposites are based on chitosan, cellulose, starch, alginate, gellan gum, poly(vinyl alcohol) (PVA), poly(acrylamide), poly(e-caprolactone) (PCL), poly(lactic acid) (PLLA), poly(lactide-co-glycolide) (PLGA), gelatin, collagen, and silk fibroin (SF). The biological and mechanical performance of such nanocomposites are comprehensively scrutinized and ongoing research questions are addressed. The analysis of the literature reveals overall the great potential of GO/ polymer nanocomposites in tissue engineering strategies and indicates also a series of challenges requiring further research efforts.

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Section: Discussionmentioning

confidence: 99%

Section: Polyacrylamidementioning

confidence: 99%

Section: Polyacrylamidementioning

confidence: 99%

Section: Plla 3d Porous Scaffoldsmentioning

confidence: 99%

Section: Synthetic Polymersmentioning

confidence: 99%

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Graphene Oxide/Polymer‐Based Biomaterials

2017

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Fault‐Tolerant and On‐Demand Supra Tough Adhesive Natural Albumin‐Based Organohydrogels

Chen,

Yang,

Liu

et al. 2024

Adv Funct Materials

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Adhesive hydrogels play a crucial role in numerous applications across fields such as wound dressing, biomedical implants, and flexible electronics. Despite recent efforts on hydrogel design, reconciling the conflicting requirements of adaptability to rough surfaces and intrinsic strength remains elusive for self‐adhesive hydrogels. To address this challenge, a novel strategy is proposed where conformal contact between hydrogels and solids is initially established in a weak state, followed by reinforcement to enhance strength and toughness. Illustrating this approach, bovine serum albumin (BSA) is employed to incorporate a flexible synthetic polymer network, resulting in soft and adhesive organohydrogels (OHGs) with instantaneous and reversible adhesion on various substrates, providing fault‐tolerant operation convenience. A brief on‐demand heating step transforms them into a strong and supra‐adhesive state by forming a rigid BSA network and establishing a double network (DN) structure. The resulting BSA based DN OHGs demonstrate remarkably enhanced bulk mechanical strength and exceptional interfacial toughness on diverse nonporous solid substrates, allowing for on‐demand permanent fixation. This approach integrates fault‐tolerance and permanent fixation into a single material, highlighting the potential of these natural albumin based OHGs as advanced functional materials for diverse applications, including artisanal restoration, and all‐season flexible sensors.

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Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?

et al. 2019

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Given their durability and long‐term stability, self‐healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility between hydrogel toughness and rapid self‐healing remains unaddressed, and therefore most of the self‐healable hydrogels still face serious challenges within the dynamic and mechanically demanding environment of human organs/tissues. Furthermore, depending on the target tissue, the self‐healing hydrogels must comply with a wide range of properties including electrical, biological, and mechanical. Notably, the incorporation of nanomaterials into double‐network hydrogels is showing great promise as a feasible way to generate self‐healable hydrogels with the above‐mentioned attributes. Here, the recent progress in the development of multifunctional and self‐healable hydrogels for various tissue engineering applications is discussed in detail. Their potential applications within the rapidly expanding areas of bioelectronic hydrogels, cyborganics, and soft robotics are further highlighted.

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One‐Pot Fabrication of a Novel Agar‐Polyacrylamide/Graphene Oxide Nanocomposite Double Network Hydrogel with High Mechanical Properties

Cited by 63 publications

References 48 publications

Graphene Oxide/Polymer‐Based Biomaterials

Graphene Oxide/Polymer‐Based Biomaterials

Fault‐Tolerant and On‐Demand Supra Tough Adhesive Natural Albumin‐Based Organohydrogels

Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?

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