One-pot conversion of dihydroxyacetone into ethyl lactate by Zr-based catalysts

Shi, Junjun; Li, Fukun; Zhang, Jie; Li, Ning; Wang, Xingmin; Zhang, Xianming; Liu, Yunqi

doi:10.1039/d1ra00775k

Cited by 2 publications

(1 citation statement)

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“…Performing the conversion reaction in methanol or ethanol instead of water produces methyl lactate and ethyl lactate, respectively ( Figure 13 ). Ethyl lactate production by this process has received a lot of interest in recent years [ 131 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 ]. Methyl lactate is also of interest, as it is both a valuable chemical and an interesting alternative route to LA synthesis if processed further by simple hydrolysis [ 148 , 149 , 150 ].…”

Section: A Multi-functional Synthesis Tool: Dha’s Broad Range Of Reac...mentioning

confidence: 99%

Dihydroxyacetone: A User Guide for a Challenging Bio-Based Synthon

et al. 2023

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1,3-dihydroxyacetone (DHA) is an underrated bio-based synthon, with a broad range of reactivities. It is produced for the revalorization of glycerol, a major side-product of the growing biodiesel industry. The overwhelming majority of DHA produced worldwide is intended for application as a self-tanning agent in cosmetic formulations. This review provides an overview of the discovery, physical and chemical properties of DHA, and of its industrial production routes from glycerol. Microbial fermentation is the only industrial-scaled route but advances in electrooxidation and aerobic oxidation are also reported. This review focuses on the plurality of reactivities of DHA to help chemists interested in bio-based building blocks see the potential of DHA for this application. The handling of DHA is delicate as it can undergo dimerization as well as isomerization reactions in aqueous solutions at room temperature. DHA can also be involved in further side-reactions, yielding original side-products, as well as compounds of interest. If this peculiar reactivity was harnessed, DHA could help address current sustainability challenges encountered in the synthesis of speciality polymers, ranging from biocompatible polymers to innovative polymers with cutting-edge properties and improved biodegradability.

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