One-pot biogenic synthesis of gold nanoparticles@saponins niosomes: Sustainable nanomedicine for antibacterial, anti-inflammatory and anticancer therapeutics

Ayyanaar, Srinivasan; Kesavan, Mookkandi Palsamy

doi:10.1016/j.colsurfa.2023.132229

Cited by 6 publications

(3 citation statements)

References 60 publications

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“…Pathogenic oral bacteria such as P. gingivalis that cause caries and bad breath can be inhibited by this group. [67][68][69][70][71]…”

Section: Saponinsmentioning

confidence: 99%

Phytochemical Analysis and Anti-Biofilm Potential That Cause Dental Caries from Black Cumin Seeds (Nigella sativa Linn.)

Kurnia,

Padilah,

Apriyanti

et al. 2024

DDDT

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The oral cavity is an excellent place for various microorganisms to grow. Spectrococcus mutans and Spectrococcus sanguinis are Gram-negative bacteria found in the oral cavity as pioneer biofilm formers on the tooth surface that cause caries. Caries treatment has been done with antibiotics and therapeutics, but the resistance level of S. mutans and S. sanguinis bacteria necessitates the exploration of new drug compounds. Black cumin (Nigella sativa Linn.) is known to contain secondary metabolites that have antioxidant, antibacterial, anti-biofilm, anti-inflammatory and antifungal activities. The purpose of this review article is to present data on the potential of Nigella sativa Linn seeds as anti-biofilm. This article will discuss biofilm-forming bacteria, the resistance mechanism of antibiotics, the bioactivity of N. sativa extracts and seed isolates together with the Structure Activity Relationship (SAR) review of N. sativa compound isolates. We collected data from reliable references that will illustrate the potential of N. sativa seeds as anti-biofilm drug.

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“…Pathogenic oral bacteria such as P. gingivalis that cause caries and bad breath can be inhibited by this group. [67][68][69][70][71]…”

Section: Saponinsmentioning

confidence: 99%

Phytochemical Analysis and Anti-Biofilm Potential That Cause Dental Caries from Black Cumin Seeds (Nigella sativa Linn.)

Kurnia,

Padilah,

Apriyanti

et al. 2024

DDDT

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“…25923) MIC = 3.9 μg/mL B. subtilis (ATCC No. 21332) MIC = 15.62 μg/mL Spherical; 3.5 nm P. aeruginosa 24 h MIC = 100 μg/mL [ 76 ] S. aureus MIC = 100 μg/mL E. coli MIC = 100 μg/mL Star; 26.0 ± 2.6 nm S. aureus (ATCC 12600) 24 h MIC = 250 μg/mL [ 77 ] CuNPs Spherical; 38 nm E. coli 24 h MIC = 350 μg/mL [ 78 ] S. aureus MIC = 150 μg/mL C. albicans <...…”

Section: Metal-based Nanoparticles In Wound Healingmentioning

confidence: 99%

Electrospun Nanofiber Scaffolds Loaded with Metal-Based Nanoparticles for Wound Healing

Dang,

Ma,

Yang

et al. 2023

Polymers

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Failures of wound healing have been a focus of research worldwide. With the continuous development of materials science, electrospun nanofiber scaffolds loaded with metal-based nanoparticles provide new ideas and methods for research into new tissue engineering materials due to their excellent antibacterial, anti-inflammatory, and wound healing abilities. In this review, the stages of extracellular matrix and wound healing, electrospun nanofiber scaffolds, metal-based nanoparticles, and metal-based nanoparticles supported by electrospun nanofiber scaffolds are reviewed, and their characteristics and applications are introduced. We discuss in detail the current research on wound healing of metal-based nanoparticles and electrospun nanofiber scaffolds loaded with metal-based nanoparticles, and we highlight the potential mechanisms and promising applications of these scaffolds for promoting wound healing.

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“…Colloidal delivery systems have aroused great interest due to their widespread applications in fields such as pharmaceutics, − food, − and cosmetics. − They are considered as effective means of solving some shortcomings of active ingredients, such as insolubility, instability, incompatibility, irritation, and rapid release. So far, several types of colloidal delivery systems, such as liposomes, ,,− niosomes, , double emulsions, − coacervates, − and microcapsules, − have been developed, whose amphiphilic structure can encapsulate hydrophobic active ingredients in hydrophobic cavities, or encapsulate hydrophilic active ingredients in hydrophilic cavities, or simultaneously encapsulate hydrophobic and hydrophilic active ingredients in hydrophobic and hydrophilic cavities, respectively. Among them, liposomes have significant advantages in encapsulating active ingredients in cosmetics.…”

Section: Introductionmentioning

confidence: 99%

Lecithin/Cholesterol/Tween 80 Liposomes for Co-Encapsulation of Vitamin C and Xanthoxylin

Wang,

Ma,

Yan

et al. 2024

ACS Appl. Nano Mater.

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Co-encapsulated hydrophilic vitamin C (Vc) and hydrophobic xanthoxylin (GX-50) liposomes (L-Vc-GX-50) were prepared using ethanol injection and ultrasonic methods and characterized by dynamical light scattering, ζ-potential, cryogenic transmission electron microscopy, UV−vis spectroscopy, Fourier transform infrared spectroscopy, antioxidant capacity, tyrosinase activity, and in vitro permeation measurements. L-Vc-GX-50 are formed by the assembly of egg yolk lecithin, cholesterol, and tween 80, with Vc and GX-50 encapsulated in their hydrophilic and hydrophobic cavities, respectively. By considering the hydrodynamic radius (R h ), ζ-potential, and encapsulation efficiency (EE) of L-Vc-GX-50, the optimum formulation was determined to be egg yolk lecithin/cholesterol/tween 80/GX-50 or Vc (15:3:3:1, w/ w) with phosphate buffer (pH 6.8, 0.01 M). The as-prepared L-Vc-GX-50 have an average R h of 114 nm, a negative ζ-potential (−23.63 mV), a high EE of Vc (73.3%) and GX-50 (87.4%), and a unilamellar vesicle structure. Compared co-encapsulated L-Vc-GX-50 with single encapsulated Vc or GX-50 liposomes (L-Vc or L-GX-50), the EE of Vc in L-Vc-GX-50 is obviously higher than that of L-Vc, while the EE of GX-50 in L-Vc-GX-50 is similar to that in L-GX-50; the antioxidant capacity and tyrosinase inhibition activity of L-Vc-GX-50 are higher than those of L-GX-50 or L-Vc. The in vitro permeation data indicate that the final cumulative permeation amount of Vc and GX-50 in L-Vc-GX-50 can reach around 2.1 and 1.3 mg/cm 2 , respectively. The release kinetics fitting data show that the release kinetics of L-Vc-GX-50 follows the Korsmeyer−Peppas model and that the release of active ingredients is mainly dominated by the synergistic effect of diffusion release and rupture release. Moreover, L-Vc-GX-50 has good low-temperature storage stability, and the storage stability of GX-50 in L-Vc-GX-50 is significantly improved compared to L-GX-50. The main objective of this study is to improve the instability of Vc and the insolubility of GX-50 in cosmetics.

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One-pot biogenic synthesis of gold nanoparticles@saponins niosomes: Sustainable nanomedicine for antibacterial, anti-inflammatory and anticancer therapeutics

Cited by 6 publications

References 60 publications

Phytochemical Analysis and Anti-Biofilm Potential That Cause Dental Caries from Black Cumin Seeds (Nigella sativa Linn.)

Phytochemical Analysis and Anti-Biofilm Potential That Cause Dental Caries from Black Cumin Seeds (Nigella sativa Linn.)

Electrospun Nanofiber Scaffolds Loaded with Metal-Based Nanoparticles for Wound Healing

Lecithin/Cholesterol/Tween 80 Liposomes for Co-Encapsulation of Vitamin C and Xanthoxylin

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